Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1032937..1033739 Replicon chromosome
Accession NZ_CP093188
Organism Staphylococcus epidermidis strain TMDU-302

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU45_RS04930 Protein ID WP_002468490.1
Coordinates 1033560..1033739 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU45_RS04925 Protein ID WP_002456349.1
Coordinates 1032937..1033536 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU45_RS04905 (MNU45_04900) 1028149..1029606 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU45_RS04910 (MNU45_04905) 1029599..1030321 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU45_RS04915 (MNU45_04910) 1031182..1032312 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU45_RS04920 (MNU45_04915) 1032309..1032779 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU45_RS04925 (MNU45_04920) 1032937..1033536 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU45_RS04930 (MNU45_04925) 1033560..1033739 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU45_RS04935 (MNU45_04930) 1033895..1034299 + 405 WP_001829818.1 hypothetical protein -
MNU45_RS04940 (MNU45_04935) 1034484..1035869 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU45_RS04945 (MNU45_04940) 1036230..1037054 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU45_RS04950 (MNU45_04945) 1037213..1038346 + 1134 WP_058649751.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237769 WP_002468490.1 NZ_CP093188:1033560-1033739 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237769 NZ_LR882934:1405114-1405449 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237769 WP_002456349.1 NZ_CP093188:1032937-1033536 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237769 NZ_LR882934:1404887-1405117 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGGATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References