Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 875106..875615 Replicon chromosome
Accession NZ_CP093188
Organism Staphylococcus epidermidis strain TMDU-302

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU45_RS04030 Protein ID WP_001829980.1
Coordinates 875406..875615 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU45_RS04025 Protein ID WP_001829893.1
Coordinates 875106..875399 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU45_RS04000 (MNU45_03995) 870114..870902 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU45_RS04005 (MNU45_04000) 870908..871546 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU45_RS04010 (MNU45_04005) 871635..872507 + 873 WP_002458703.1 membrane protein insertase YidC -
MNU45_RS04015 (MNU45_04010) 872613..873266 - 654 WP_001829983.1 HD domain-containing protein -
MNU45_RS04020 (MNU45_04015) 873448..874932 - 1485 WP_002457116.1 cardiolipin synthase -
MNU45_RS04025 (MNU45_04020) 875106..875399 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU45_RS04030 (MNU45_04025) 875406..875615 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU45_RS04035 (MNU45_04030) 875758..875895 + 138 WP_001829949.1 Lmo0850 family protein -
MNU45_RS04040 (MNU45_04035) 875995..877206 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU45_RS04045 (MNU45_04040) 877597..878670 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU45_RS04050 (MNU45_04045) 878682..880037 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237767 WP_001829980.1 NZ_CP093188:875406-875615 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237767 NZ_LR882500:c3788729-3788337 [Mycobacterium tuberculosis variant microti]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237767 WP_001829893.1 NZ_CP093188:875106-875399 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237767 NZ_LR882500:c3789004-3788729 [Mycobacterium tuberculosis variant microti]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References