Detailed information of TA system TA237766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1970879..1971349
• Replicon: chromosome
• Accession: NZ_CP093185
• Organism: Staphylococcus epidermidis strain TMDU-300

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MNU53_RS09260
• Protein ID: WP_001829569.1
• Coordinates: 1971161..1971349 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MNU53_RS09255
• Protein ID: WP_002438963.1
• Coordinates: 1970879..1971136 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU53_RS09220 (MNU53_09210)	1966167..1966304	-	138	WP_162161215.1	hypothetical protein	-
MNU53_RS09225 (MNU53_09215)	1966334..1966521	-	188	Protein_1783	hypothetical protein	-
MNU53_RS09230 (MNU53_09220)	1966671..1967849	-	1179	WP_157173500.1	IS110-like element ISSep2 family transposase	-
MNU53_RS09235 (MNU53_09225)	1968467..1968967	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MNU53_RS09240 (MNU53_09230)	1969238..1969825	-	588	WP_002469329.1	histidine phosphatase family protein	-
MNU53_RS09245 (MNU53_09235)	1970039..1970275	+	237	WP_002457224.1	hypothetical protein	-
MNU53_RS09250 (MNU53_09240)	1970267..1970470	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MNU53_RS09255 (MNU53_09245)	1970879..1971136	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MNU53_RS09260 (MNU53_09250)	1971161..1971349	+	189	WP_001829569.1	hypothetical protein	Toxin
MNU53_RS09265 (MNU53_09255)	1971539..1972093	+	555	Protein_1791	hypothetical protein	-
MNU53_RS09270 (MNU53_09260)	1972153..1972386	-	234	WP_001829664.1	hypothetical protein	-
MNU53_RS09275 (MNU53_09265)	1972670..1973416	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MNU53_RS09280 (MNU53_09270)	1973515..1973799	+	285	WP_001829635.1	hypothetical protein	-
MNU53_RS09285 (MNU53_09275)	1973823..1974047	+	225	WP_001829613.1	hypothetical protein	-
MNU53_RS09290 (MNU53_09280)	1974668..1974868	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1965558..1986130	20572

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T237766 WP_001829569.1 NZ_CP093185:1971161-1971349 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237766 NZ_LR882500:3761486-3761743 [Mycobacterium tuberculosis variant microti]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237766 WP_002438963.1 NZ_CP093185:1970879-1971136 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237766 NZ_LR882500:3761214-3761489 [Mycobacterium tuberculosis variant microti]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3