Detailed information of TA system TA237765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1015634..1016436
• Replicon: chromosome
• Accession: NZ_CP093185
• Organism: Staphylococcus epidermidis strain TMDU-300

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: MNU53_RS04850
• Protein ID: WP_002468490.1
• Coordinates: 1016257..1016436 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MNU53_RS04845
• Protein ID: WP_002486232.1
• Coordinates: 1015634..1016233 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU53_RS04825 (MNU53_04820)	1010846..1012303	+	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-
MNU53_RS04830 (MNU53_04825)	1012296..1013018	+	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
MNU53_RS04835 (MNU53_04830)	1013879..1015009	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
MNU53_RS04840 (MNU53_04835)	1015006..1015476	+	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MNU53_RS04845 (MNU53_04840)	1015634..1016233	+	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
MNU53_RS04850 (MNU53_04845)	1016257..1016436	+	180	WP_002468490.1	SAS053 family protein	Toxin
MNU53_RS04855 (MNU53_04850)	1016592..1016996	+	405	WP_002485605.1	hypothetical protein	-
MNU53_RS04860 (MNU53_04855)	1017181..1018566	+	1386	WP_001829862.1	class II fumarate hydratase	-
MNU53_RS04865 (MNU53_04860)	1018927..1019751	-	825	WP_001829804.1	RluA family pseudouridine synthase	-
MNU53_RS04870 (MNU53_04865)	1019910..1021043	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T237765 WP_002468490.1 NZ_CP093185:1016257-1016436 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T237765 NZ_LR882500:c3712349-3711921 [Mycobacterium tuberculosis variant microti]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGCGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT237765 WP_002486232.1 NZ_CP093185:1015634-1016233 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT237765 NZ_LR882500:c3712595-3712353 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44