Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 866889..867398 Replicon chromosome
Accession NZ_CP093185
Organism Staphylococcus epidermidis strain TMDU-300

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU53_RS03995 Protein ID WP_001829980.1
Coordinates 867189..867398 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU53_RS03990 Protein ID WP_001829893.1
Coordinates 866889..867182 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU53_RS03965 (MNU53_03960) 861897..862685 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MNU53_RS03970 (MNU53_03965) 862691..863329 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU53_RS03975 (MNU53_03970) 863418..864290 + 873 WP_002470121.1 membrane protein insertase YidC -
MNU53_RS03980 (MNU53_03975) 864396..865049 - 654 WP_001829983.1 HD domain-containing protein -
MNU53_RS03985 (MNU53_03980) 865231..866715 - 1485 WP_002457116.1 cardiolipin synthase -
MNU53_RS03990 (MNU53_03985) 866889..867182 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU53_RS03995 (MNU53_03990) 867189..867398 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU53_RS04000 (MNU53_03995) 867541..867678 + 138 WP_001829949.1 Lmo0850 family protein -
MNU53_RS04005 (MNU53_04000) 867777..868988 - 1212 WP_002487881.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU53_RS04010 (MNU53_04005) 869379..870452 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU53_RS04015 (MNU53_04010) 870464..871819 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237763 WP_001829980.1 NZ_CP093185:867189-867398 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237763 NZ_LR882500:3182781-3183224 [Mycobacterium tuberculosis variant microti]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237763 WP_001829893.1 NZ_CP093185:866889-867182 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237763 NZ_LR882500:3182537-3182794 [Mycobacterium tuberculosis variant microti]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References