Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1890594..1891103 Replicon chromosome
Accession NZ_CP093181
Organism Staphylococcus epidermidis strain TMDU-265

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU40_RS09380 Protein ID WP_001829980.1
Coordinates 1890594..1890803 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU40_RS09385 Protein ID WP_001829893.1
Coordinates 1890810..1891103 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU40_RS09360 (MNU40_09365) 1886172..1887527 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MNU40_RS09365 (MNU40_09370) 1887539..1888612 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU40_RS09370 (MNU40_09375) 1889003..1890214 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU40_RS09375 (MNU40_09380) 1890314..1890451 - 138 WP_001829949.1 Lmo0850 family protein -
MNU40_RS09380 (MNU40_09385) 1890594..1890803 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU40_RS09385 (MNU40_09390) 1890810..1891103 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU40_RS09390 (MNU40_09395) 1891277..1892761 + 1485 WP_002457116.1 cardiolipin synthase -
MNU40_RS09395 (MNU40_09400) 1892943..1893596 + 654 WP_001829983.1 HD domain-containing protein -
MNU40_RS09400 (MNU40_09405) 1893702..1894574 - 873 WP_002458703.1 membrane protein insertase YidC -
MNU40_RS09405 (MNU40_09410) 1894663..1895301 - 639 WP_002505076.1 thiamine phosphate synthase -
MNU40_RS09410 (MNU40_09415) 1895307..1896095 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237762 WP_001829980.1 NZ_CP093181:c1890803-1890594 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237762 NZ_LR882500:3177221-3177484 [Mycobacterium tuberculosis variant microti]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237762 WP_001829893.1 NZ_CP093181:c1891103-1890810 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237762 NZ_LR882500:3176936-3177217 [Mycobacterium tuberculosis variant microti]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References