Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241088..241730 Replicon chromosome
Accession NC_012659
Organism Bacillus anthracis str. A0248

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BAA_RS01865 Protein ID WP_000635963.1
Coordinates 241380..241730 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BAA_RS01860 Protein ID WP_000004570.1
Coordinates 241088..241375 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA_RS01835 236404..237366 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
BAA_RS01840 237359..237931 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
BAA_RS01845 238024..238383 + 360 WP_000635040.1 holo-ACP synthase -
BAA_RS01850 238540..239490 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
BAA_RS01855 239609..240778 + 1170 WP_000390596.1 alanine racemase -
BAA_RS01860 241088..241375 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BAA_RS01865 241380..241730 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BAA_RS01870 241798..243966 + 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
BAA_RS01875 244024..244140 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BAA_RS01880 244336..244794 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T23776 WP_000635963.1 NC_012659:241380-241730 [Bacillus anthracis str. A0248]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T23776 NC_012659:241380-241730 [Bacillus anthracis str. A0248]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT23776 WP_000004570.1 NC_012659:241088-241375 [Bacillus anthracis str. A0248]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT23776 NC_012659:241088-241375 [Bacillus anthracis str. A0248]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References