Detailed information of TA system TA237758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 665098..665901
• Replicon: chromosome
• Accession: NZ_CP093181
• Organism: Staphylococcus epidermidis strain TMDU-265

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU40_RS03280
• Protein ID: WP_002484735.1
• Coordinates: 665098..665559 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU40_RS03285
• Protein ID: WP_002484747.1
• Coordinates: 665572..665901 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU40_RS03240 (MNU40_03245)	660344..660562	-	219	WP_001829292.1	IDEAL domain-containing protein	-
MNU40_RS03245 (MNU40_03250)	660777..661352	+	576	WP_001829272.1	competence protein ComK	-
MNU40_RS03260 (MNU40_03265)	661753..662802	-	1050	WP_001830299.1	site-specific integrase	-
MNU40_RS03265 (MNU40_03270)	662865..663416	-	552	WP_103422871.1	Ltp family lipoprotein	-
MNU40_RS03270 (MNU40_03275)	663601..664740	-	1140	WP_103422872.1	CapA family protein	-
MNU40_RS03275 (MNU40_03280)	664762..664929	-	168	WP_002497581.1	hypothetical protein	-
MNU40_RS03280 (MNU40_03285)	665098..665559	-	462	WP_002484735.1	ImmA/IrrE family metallo-endopeptidase	Toxin
MNU40_RS03285 (MNU40_03290)	665572..665901	-	330	WP_002484747.1	helix-turn-helix transcriptional regulator	Antitoxin
MNU40_RS03290 (MNU40_03295)	666095..666334	+	240	WP_194086740.1	helix-turn-helix transcriptional regulator	-
MNU40_RS03295 (MNU40_03300)	666348..667064	+	717	WP_002468739.1	phage repressor protein	-
MNU40_RS03300 (MNU40_03305)	667077..667286	+	210	WP_001830281.1	hypothetical protein	-
MNU40_RS03305 (MNU40_03310)	667413..667679	-	267	WP_002456364.1	hypothetical protein	-
MNU40_RS03310 (MNU40_03315)	668012..669964	+	1953	WP_194086741.1	AAA family ATPase	-
MNU40_RS03315 (MNU40_03320)	669966..670889	+	924	WP_059223500.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	661753..703860	42107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (33-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17881.48 Da
• Isoelectric Point: 5.0503

>T237758 WP_002484735.1 NZ_CP093181:c665559-665098 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Nucleotide

• Length: 462 bp

>T237758 NZ_LR882500:c3074726-3074331 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12708.21 Da
• Isoelectric Point: 4.8033

>AT237758 WP_002484747.1 NZ_CP093181:c665901-665572 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPQH
RAAHLDGDLTDEEWQEILDYAEYIRSKRK

Nucleotide

• Length: 330 bp

>AT237758 NZ_LR882500:c3074305-3074039 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA