Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 525735..526205 Replicon chromosome
Accession NZ_CP093181
Organism Staphylococcus epidermidis strain TMDU-265

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MNU40_RS02555 Protein ID WP_001829569.1
Coordinates 525735..525923 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MNU40_RS02560 Protein ID WP_002438963.1
Coordinates 525948..526205 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU40_RS02525 (MNU40_02530) 522216..522416 + 201 WP_001829681.1 cold-shock protein -
MNU40_RS02530 (MNU40_02535) 523037..523261 - 225 WP_001829613.1 hypothetical protein -
MNU40_RS02535 (MNU40_02540) 523285..523569 - 285 WP_001829635.1 hypothetical protein -
MNU40_RS02540 (MNU40_02545) 523668..524414 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
MNU40_RS02545 (MNU40_02550) 524698..524931 + 234 WP_001829664.1 hypothetical protein -
MNU40_RS02550 (MNU40_02555) 524991..525545 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MNU40_RS02555 (MNU40_02560) 525735..525923 - 189 WP_001829569.1 hypothetical protein Toxin
MNU40_RS02560 (MNU40_02565) 525948..526205 - 258 WP_002438963.1 hypothetical protein Antitoxin
MNU40_RS02565 (MNU40_02570) 526614..526817 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
MNU40_RS02570 (MNU40_02575) 526809..527045 - 237 WP_002457224.1 hypothetical protein -
MNU40_RS02575 (MNU40_02580) 527259..527846 + 588 WP_001829615.1 histidine phosphatase family protein -
MNU40_RS02580 (MNU40_02585) 528114..528614 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
MNU40_RS02585 (MNU40_02590) 529001..529188 + 188 Protein_491 hypothetical protein -
MNU40_RS02590 (MNU40_02595) 529200..529355 + 156 WP_001829648.1 hypothetical protein -
MNU40_RS02595 (MNU40_02600) 529539..529961 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
MNU40_RS02600 (MNU40_02605) 530122..530838 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 507523..529964 22441
- flank IS/Tn - - 529200..529355 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T237757 WP_001829569.1 NZ_CP093181:c525923-525735 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T237757 NZ_LR882500:c3074042-3073626 [Mycobacterium tuberculosis variant microti]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT237757 WP_002438963.1 NZ_CP093181:c526205-525948 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT237757 NZ_LR882500:c3074305-3074039 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References