Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1944243..1944752 Replicon chromosome
Accession NZ_CP093179
Organism Staphylococcus epidermidis strain TMDU-190

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU31_RS09645 Protein ID WP_001829980.1
Coordinates 1944243..1944452 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU31_RS09650 Protein ID WP_001829893.1
Coordinates 1944459..1944752 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU31_RS09625 (MNU31_09630) 1939821..1941176 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MNU31_RS09630 (MNU31_09635) 1941188..1942261 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU31_RS09635 (MNU31_09640) 1942652..1943863 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU31_RS09640 (MNU31_09645) 1943963..1944100 - 138 WP_001829949.1 Lmo0850 family protein -
MNU31_RS09645 (MNU31_09650) 1944243..1944452 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU31_RS09650 (MNU31_09655) 1944459..1944752 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU31_RS09655 (MNU31_09660) 1944926..1946410 + 1485 WP_002457116.1 cardiolipin synthase -
MNU31_RS09660 (MNU31_09665) 1946592..1947245 + 654 WP_001829983.1 HD domain-containing protein -
MNU31_RS09665 (MNU31_09670) 1947351..1948223 - 873 WP_002458703.1 membrane protein insertase YidC -
MNU31_RS09670 (MNU31_09675) 1948312..1948950 - 639 WP_002505076.1 thiamine phosphate synthase -
MNU31_RS09675 (MNU31_09680) 1948956..1949744 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237756 WP_001829980.1 NZ_CP093179:c1944452-1944243 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237756 NZ_LR882500:c2980412-2980089 [Mycobacterium tuberculosis variant microti]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237756 WP_001829893.1 NZ_CP093179:c1944752-1944459 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237756 NZ_LR882500:c2980737-2980492 [Mycobacterium tuberculosis variant microti]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References