Detailed information of TA system TA237752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 718877..719680
• Replicon: chromosome
• Accession: NZ_CP093179
• Organism: Staphylococcus epidermidis strain TMDU-190

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU31_RS03545
• Protein ID: WP_002484735.1
• Coordinates: 718877..719338 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNU31_RS03550
• Protein ID: WP_002484747.1
• Coordinates: 719351..719680 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU31_RS03505 (MNU31_03510)	714123..714341	-	219	WP_001829292.1	IDEAL domain-containing protein	-
MNU31_RS03510 (MNU31_03515)	714556..715131	+	576	WP_001829272.1	competence protein ComK	-
MNU31_RS03525 (MNU31_03530)	715532..716581	-	1050	WP_001830299.1	site-specific integrase	-
MNU31_RS03530 (MNU31_03535)	716644..717195	-	552	WP_103422871.1	Ltp family lipoprotein	-
MNU31_RS03535 (MNU31_03540)	717380..718519	-	1140	WP_103422872.1	CapA family protein	-
MNU31_RS03540 (MNU31_03545)	718541..718708	-	168	WP_002497581.1	hypothetical protein	-
MNU31_RS03545 (MNU31_03550)	718877..719338	-	462	WP_002484735.1	ImmA/IrrE family metallo-endopeptidase	Toxin
MNU31_RS03550 (MNU31_03555)	719351..719680	-	330	WP_002484747.1	helix-turn-helix transcriptional regulator	Antitoxin
MNU31_RS03555 (MNU31_03560)	719874..720113	+	240	WP_194086740.1	helix-turn-helix transcriptional regulator	-
MNU31_RS03560 (MNU31_03565)	720127..720843	+	717	WP_002468739.1	phage repressor protein	-
MNU31_RS03565 (MNU31_03570)	720856..721065	+	210	WP_001830281.1	hypothetical protein	-
MNU31_RS03570 (MNU31_03575)	721192..721458	-	267	WP_002456364.1	hypothetical protein	-
MNU31_RS03575 (MNU31_03580)	721791..723743	+	1953	WP_254104848.1	AAA family ATPase	-
MNU31_RS03580 (MNU31_03585)	723745..724668	+	924	WP_059223500.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	715532..757639	42107

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (33-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17881.48 Da
• Isoelectric Point: 5.0503

>T237752 WP_002484735.1 NZ_CP093179:c719338-718877 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Nucleotide

• Length: 462 bp

>T237752 NZ_LR882500:2871626-2872039 [Mycobacterium tuberculosis variant microti]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12708.21 Da
• Isoelectric Point: 4.8033

>AT237752 WP_002484747.1 NZ_CP093179:c719680-719351 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPQH
RAAHLDGDLTDEEWQEILDYAEYIRSKRK

Nucleotide

• Length: 330 bp

>AT237752 NZ_LR882500:2872078-2872335 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA