Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 572774..573244 | Replicon | chromosome |
| Accession | NZ_CP093179 | ||
| Organism | Staphylococcus epidermidis strain TMDU-190 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | MNU31_RS02785 | Protein ID | WP_001829569.1 |
| Coordinates | 572774..572962 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | MNU31_RS02790 | Protein ID | WP_002438963.1 |
| Coordinates | 572987..573244 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU31_RS02755 (MNU31_02760) | 569255..569455 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| MNU31_RS02760 (MNU31_02765) | 570076..570300 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| MNU31_RS02765 (MNU31_02770) | 570324..570608 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| MNU31_RS02770 (MNU31_02775) | 570707..571453 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| MNU31_RS02775 (MNU31_02780) | 571737..571970 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| MNU31_RS02780 (MNU31_02785) | 572030..572584 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| MNU31_RS02785 (MNU31_02790) | 572774..572962 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| MNU31_RS02790 (MNU31_02795) | 572987..573244 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| MNU31_RS02795 (MNU31_02800) | 573653..573856 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| MNU31_RS02800 (MNU31_02805) | 573848..574084 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| MNU31_RS02805 (MNU31_02810) | 574298..574885 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| MNU31_RS02810 (MNU31_02815) | 575156..575656 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| MNU31_RS02815 (MNU31_02820) | 576043..576230 | + | 188 | Protein_541 | hypothetical protein | - |
| MNU31_RS02820 (MNU31_02825) | 576260..576397 | + | 138 | WP_162161215.1 | hypothetical protein | - |
| MNU31_RS02825 (MNU31_02830) | 576581..577003 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| MNU31_RS02830 (MNU31_02835) | 577164..577880 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 576242..576397 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T237751 WP_001829569.1 NZ_CP093179:c572962-572774 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T237751 NZ_LR882500:c2858157-2857738 [Mycobacterium tuberculosis variant microti]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT237751 WP_002438963.1 NZ_CP093179:c573244-572987 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT237751 NZ_LR882500:c2858378-2858154 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGTTGCAGATTGATGATGATATTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA
ATGCGCACCACGTTGCAGATTGATGATGATATTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |