Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2029600..2030070 | Replicon | chromosome |
| Accession | NZ_CP093173 | ||
| Organism | Staphylococcus epidermidis strain TMDU-137 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | MNU44_RS09670 | Protein ID | WP_001829569.1 |
| Coordinates | 2029882..2030070 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | MNU44_RS09665 | Protein ID | WP_002438963.1 |
| Coordinates | 2029600..2029857 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU44_RS09625 (MNU44_09615) | 2024966..2025682 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| MNU44_RS09630 (MNU44_09620) | 2025843..2026265 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| MNU44_RS09635 (MNU44_09625) | 2026449..2026586 | - | 138 | WP_162161215.1 | hypothetical protein | - |
| MNU44_RS09640 (MNU44_09630) | 2026616..2026803 | - | 188 | Protein_1866 | hypothetical protein | - |
| MNU44_RS09645 (MNU44_09635) | 2027189..2027689 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| MNU44_RS09650 (MNU44_09640) | 2027960..2028547 | - | 588 | WP_002469329.1 | histidine phosphatase family protein | - |
| MNU44_RS09655 (MNU44_09645) | 2028761..2028997 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| MNU44_RS09660 (MNU44_09650) | 2028989..2029192 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| MNU44_RS09665 (MNU44_09655) | 2029600..2029857 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| MNU44_RS09670 (MNU44_09660) | 2029882..2030070 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| MNU44_RS09675 (MNU44_09665) | 2030260..2030814 | + | 555 | WP_002469327.1 | lipoprotein N-acylation protein LnsA | - |
| MNU44_RS09680 (MNU44_09670) | 2030874..2031107 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| MNU44_RS09685 (MNU44_09675) | 2031391..2032137 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| MNU44_RS09690 (MNU44_09680) | 2032236..2032520 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| MNU44_RS09695 (MNU44_09685) | 2032544..2032768 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| MNU44_RS09700 (MNU44_09690) | 2033389..2033589 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2026449..2044161 | 17712 | |
| - | flank | IS/Tn | - | - | 2026449..2026604 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T237749 WP_001829569.1 NZ_CP093173:2029882-2030070 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T237749 NZ_LR882500:c2408513-2408196 [Mycobacterium tuberculosis variant microti]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT237749 WP_002438963.1 NZ_CP093173:2029600-2029857 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT237749 NZ_LR882500:c2408725-2408510 [Mycobacterium tuberculosis variant microti]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |