Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2029600..2030070 Replicon chromosome
Accession NZ_CP093173
Organism Staphylococcus epidermidis strain TMDU-137

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MNU44_RS09670 Protein ID WP_001829569.1
Coordinates 2029882..2030070 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MNU44_RS09665 Protein ID WP_002438963.1
Coordinates 2029600..2029857 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU44_RS09625 (MNU44_09615) 2024966..2025682 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MNU44_RS09630 (MNU44_09620) 2025843..2026265 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MNU44_RS09635 (MNU44_09625) 2026449..2026586 - 138 WP_162161215.1 hypothetical protein -
MNU44_RS09640 (MNU44_09630) 2026616..2026803 - 188 Protein_1866 hypothetical protein -
MNU44_RS09645 (MNU44_09635) 2027189..2027689 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MNU44_RS09650 (MNU44_09640) 2027960..2028547 - 588 WP_002469329.1 histidine phosphatase family protein -
MNU44_RS09655 (MNU44_09645) 2028761..2028997 + 237 WP_002457224.1 hypothetical protein -
MNU44_RS09660 (MNU44_09650) 2028989..2029192 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
MNU44_RS09665 (MNU44_09655) 2029600..2029857 + 258 WP_002438963.1 hypothetical protein Antitoxin
MNU44_RS09670 (MNU44_09660) 2029882..2030070 + 189 WP_001829569.1 hypothetical protein Toxin
MNU44_RS09675 (MNU44_09665) 2030260..2030814 + 555 WP_002469327.1 lipoprotein N-acylation protein LnsA -
MNU44_RS09680 (MNU44_09670) 2030874..2031107 - 234 WP_001829664.1 hypothetical protein -
MNU44_RS09685 (MNU44_09675) 2031391..2032137 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
MNU44_RS09690 (MNU44_09680) 2032236..2032520 + 285 WP_001829635.1 hypothetical protein -
MNU44_RS09695 (MNU44_09685) 2032544..2032768 + 225 WP_001829613.1 hypothetical protein -
MNU44_RS09700 (MNU44_09690) 2033389..2033589 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2026449..2044161 17712
- flank IS/Tn - - 2026449..2026604 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T237749 WP_001829569.1 NZ_CP093173:2029882-2030070 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T237749 NZ_LR882500:c2408513-2408196 [Mycobacterium tuberculosis variant microti]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT237749 WP_002438963.1 NZ_CP093173:2029600-2029857 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT237749 NZ_LR882500:c2408725-2408510 [Mycobacterium tuberculosis variant microti]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References