Detailed information of TA system TA237748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1026387..1027189
• Replicon: chromosome
• Accession: NZ_CP093173
• Organism: Staphylococcus epidermidis strain TMDU-137

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: MNU44_RS04885
• Protein ID: WP_002468490.1
• Coordinates: 1027010..1027189 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MNU44_RS04880
• Protein ID: WP_002486232.1
• Coordinates: 1026387..1026986 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU44_RS04860 (MNU44_04855)	1021599..1023056	+	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-
MNU44_RS04865 (MNU44_04860)	1023049..1023771	+	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
MNU44_RS04870 (MNU44_04865)	1024632..1025762	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
MNU44_RS04875 (MNU44_04870)	1025759..1026229	+	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MNU44_RS04880 (MNU44_04875)	1026387..1026986	+	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
MNU44_RS04885 (MNU44_04880)	1027010..1027189	+	180	WP_002468490.1	SAS053 family protein	Toxin
MNU44_RS04890 (MNU44_04885)	1027345..1027749	+	405	WP_002485605.1	hypothetical protein	-
MNU44_RS04895 (MNU44_04890)	1027934..1029319	+	1386	WP_001829862.1	class II fumarate hydratase	-
MNU44_RS04900 (MNU44_04895)	1029680..1030504	-	825	WP_001829804.1	RluA family pseudouridine synthase	-
MNU44_RS04905 (MNU44_04900)	1030663..1031796	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T237748 WP_002468490.1 NZ_CP093173:1027010-1027189 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T237748 NZ_LR882500:c2371861-2371427 [Mycobacterium tuberculosis variant microti]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT237748 WP_002486232.1 NZ_CP093173:1026387-1026986 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT237748 NZ_LR882500:c2372122-2371868 [Mycobacterium tuberculosis variant microti]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Toxin

• AlphaFold DB: A0A2G7HY44