Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 879741..880270 Replicon chromosome
Accession NZ_CP093173
Organism Staphylococcus epidermidis strain TMDU-137

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU44_RS04045 Protein ID WP_001829891.1
Coordinates 879908..880270 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU44_RS04040 Protein ID WP_001829931.1
Coordinates 879741..879911 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU44_RS04015 (MNU44_04010) 875566..876045 + 480 WP_001829909.1 PH domain-containing protein -
MNU44_RS04020 (MNU44_04015) 876038..877543 + 1506 WP_001829976.1 PH domain-containing protein -
MNU44_RS04025 (MNU44_04020) 877530..878039 + 510 WP_001829888.1 PH domain-containing protein -
MNU44_RS04030 (MNU44_04025) 878087..878440 + 354 WP_001829915.1 holo-ACP synthase -
MNU44_RS04035 (MNU44_04030) 878506..879654 + 1149 WP_001829972.1 alanine racemase -
MNU44_RS04040 (MNU44_04035) 879741..879911 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU44_RS04045 (MNU44_04040) 879908..880270 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU44_RS04050 (MNU44_04045) 880615..881616 + 1002 WP_225088278.1 PP2C family protein-serine/threonine phosphatase -
MNU44_RS04055 (MNU44_04050) 881716..882042 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU44_RS04060 (MNU44_04055) 882044..882523 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MNU44_RS04065 (MNU44_04060) 882498..883268 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237747 WP_001829891.1 NZ_CP093173:879908-880270 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237747 NZ_LR882500:2326395-2326805 [Mycobacterium tuberculosis variant microti]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237747 WP_001829931.1 NZ_CP093173:879741-879911 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237747 NZ_LR882500:2326169-2326402 [Mycobacterium tuberculosis variant microti]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References