Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 868558..869067 Replicon chromosome
Accession NZ_CP093173
Organism Staphylococcus epidermidis strain TMDU-137

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU44_RS03985 Protein ID WP_001829980.1
Coordinates 868858..869067 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU44_RS03980 Protein ID WP_001829893.1
Coordinates 868558..868851 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU44_RS03955 (MNU44_03950) 863566..864354 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MNU44_RS03960 (MNU44_03955) 864360..864998 + 639 WP_225088279.1 thiamine phosphate synthase -
MNU44_RS03965 (MNU44_03960) 865087..865959 + 873 WP_001832740.1 membrane protein insertase YidC -
MNU44_RS03970 (MNU44_03965) 866065..866718 - 654 WP_001829983.1 HD domain-containing protein -
MNU44_RS03975 (MNU44_03970) 866900..868384 - 1485 WP_001829964.1 cardiolipin synthase -
MNU44_RS03980 (MNU44_03975) 868558..868851 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU44_RS03985 (MNU44_03980) 868858..869067 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU44_RS03990 (MNU44_03985) 869210..869347 + 138 WP_001829949.1 Lmo0850 family protein -
MNU44_RS03995 (MNU44_03990) 869447..870658 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU44_RS04000 (MNU44_03995) 871049..872122 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MNU44_RS04005 (MNU44_04000) 872134..873489 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237746 WP_001829980.1 NZ_CP093173:868858-869067 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237746 NZ_LR882500:2258612-2259010 [Mycobacterium tuberculosis variant microti]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237746 WP_001829893.1 NZ_CP093173:868558-868851 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237746 NZ_LR882500:2258384-2258611 [Mycobacterium tuberculosis variant microti]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References