Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2032980..2033450 | Replicon | chromosome |
| Accession | NZ_CP093170 | ||
| Organism | Staphylococcus epidermidis strain TMDU-128 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | A0A939NNQ7 |
| Locus tag | MNU35_RS09660 | Protein ID | WP_002445998.1 |
| Coordinates | 2033262..2033450 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | A0A829M688 |
| Locus tag | MNU35_RS09655 | Protein ID | WP_002445999.1 |
| Coordinates | 2032980..2033237 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU35_RS09620 (MNU35_09615) | 2028246..2028788 | - | 543 | WP_002490759.1 | nitroreductase | - |
| MNU35_RS09625 (MNU35_09620) | 2028869..2029585 | - | 717 | WP_002475962.1 | type I 3-dehydroquinate dehydratase | - |
| MNU35_RS09630 (MNU35_09625) | 2029746..2030168 | + | 423 | WP_237641408.1 | organic hydroperoxide resistance protein | - |
| MNU35_RS09635 (MNU35_09630) | 2030574..2031074 | + | 501 | WP_002446003.1 | GNAT family N-acetyltransferase | - |
| MNU35_RS09640 (MNU35_09635) | 2031345..2031932 | - | 588 | WP_002490737.1 | histidine phosphatase family protein | - |
| MNU35_RS09645 (MNU35_09640) | 2032146..2032382 | + | 237 | WP_002446001.1 | hypothetical protein | - |
| MNU35_RS09650 (MNU35_09645) | 2032374..2032577 | - | 204 | WP_002446000.1 | sterile alpha motif-like domain-containing protein | - |
| MNU35_RS09655 (MNU35_09650) | 2032980..2033237 | + | 258 | WP_002445999.1 | hypothetical protein | Antitoxin |
| MNU35_RS09660 (MNU35_09655) | 2033262..2033450 | + | 189 | WP_002445998.1 | hypothetical protein | Toxin |
| MNU35_RS09665 (MNU35_09660) | 2033640..2034194 | + | 555 | WP_002490730.1 | lipoprotein N-acylation protein LnsA | - |
| MNU35_RS09670 (MNU35_09665) | 2034252..2034485 | - | 234 | WP_002445996.1 | hypothetical protein | - |
| MNU35_RS09675 (MNU35_09670) | 2034699..2035445 | + | 747 | WP_002445995.1 | poly-gamma-glutamate hydrolase family protein | - |
| MNU35_RS09680 (MNU35_09675) | 2035544..2035828 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| MNU35_RS09685 (MNU35_09680) | 2035853..2036077 | + | 225 | WP_002474944.1 | hypothetical protein | - |
| MNU35_RS09690 (MNU35_09685) | 2036763..2038079 | + | 1317 | WP_126122664.1 | ISL3 family transposase | - |
| MNU35_RS09695 (MNU35_09690) | 2038192..2038392 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2021418..2065643 | 44225 | |
| - | flank | IS/Tn | - | - | 2036763..2038079 | 1316 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7257.95 Da Isoelectric Point: 9.8369
>T237745 WP_002445998.1 NZ_CP093170:2033262-2033450 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T237745 NZ_LR882500:c2234988-2234644 [Mycobacterium tuberculosis variant microti]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT237745 WP_002445999.1 NZ_CP093170:2032980-2033237 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT237745 NZ_LR882500:c2235230-2234982 [Mycobacterium tuberculosis variant microti]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|