Detailed information of TA system TA237745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2032980..2033450
• Replicon: chromosome
• Accession: NZ_CP093170
• Organism: Staphylococcus epidermidis strain TMDU-128

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A939NNQ7
• Locus tag: MNU35_RS09660
• Protein ID: WP_002445998.1
• Coordinates: 2033262..2033450 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A829M688
• Locus tag: MNU35_RS09655
• Protein ID: WP_002445999.1
• Coordinates: 2032980..2033237 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU35_RS09620 (MNU35_09615)	2028246..2028788	-	543	WP_002490759.1	nitroreductase	-
MNU35_RS09625 (MNU35_09620)	2028869..2029585	-	717	WP_002475962.1	type I 3-dehydroquinate dehydratase	-
MNU35_RS09630 (MNU35_09625)	2029746..2030168	+	423	WP_237641408.1	organic hydroperoxide resistance protein	-
MNU35_RS09635 (MNU35_09630)	2030574..2031074	+	501	WP_002446003.1	GNAT family N-acetyltransferase	-
MNU35_RS09640 (MNU35_09635)	2031345..2031932	-	588	WP_002490737.1	histidine phosphatase family protein	-
MNU35_RS09645 (MNU35_09640)	2032146..2032382	+	237	WP_002446001.1	hypothetical protein	-
MNU35_RS09650 (MNU35_09645)	2032374..2032577	-	204	WP_002446000.1	sterile alpha motif-like domain-containing protein	-
MNU35_RS09655 (MNU35_09650)	2032980..2033237	+	258	WP_002445999.1	hypothetical protein	Antitoxin
MNU35_RS09660 (MNU35_09655)	2033262..2033450	+	189	WP_002445998.1	hypothetical protein	Toxin
MNU35_RS09665 (MNU35_09660)	2033640..2034194	+	555	WP_002490730.1	lipoprotein N-acylation protein LnsA	-
MNU35_RS09670 (MNU35_09665)	2034252..2034485	-	234	WP_002445996.1	hypothetical protein	-
MNU35_RS09675 (MNU35_09670)	2034699..2035445	+	747	WP_002445995.1	poly-gamma-glutamate hydrolase family protein	-
MNU35_RS09680 (MNU35_09675)	2035544..2035828	+	285	WP_001829635.1	hypothetical protein	-
MNU35_RS09685 (MNU35_09680)	2035853..2036077	+	225	WP_002474944.1	hypothetical protein	-
MNU35_RS09690 (MNU35_09685)	2036763..2038079	+	1317	WP_126122664.1	ISL3 family transposase	-
MNU35_RS09695 (MNU35_09690)	2038192..2038392	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2021418..2065643	44225
	-	flank	IS/Tn	-	-	2036763..2038079	1316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-38)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7257.95 Da
• Isoelectric Point: 9.8369

>T237745 WP_002445998.1 NZ_CP093170:2033262-2033450 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T237745 NZ_LR882500:c2234988-2234644 [Mycobacterium tuberculosis variant microti]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT237745 WP_002445999.1 NZ_CP093170:2032980-2033237 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT237745 NZ_LR882500:c2235230-2234982 [Mycobacterium tuberculosis variant microti]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A829M688