Detailed information of TA system TA237744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1048913..1049718
• Replicon: chromosome
• Accession: NZ_CP093170
• Organism: Staphylococcus epidermidis strain TMDU-128

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MNU35_RS05080
• Protein ID: WP_002457885.1
• Coordinates: 1049536..1049718 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0E1VBD1
• Locus tag: MNU35_RS05075
• Protein ID: WP_002446763.1
• Coordinates: 1048913..1049512 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU35_RS05055 (MNU35_05060)	1044623..1046080	+	1458	WP_162156237.1	ABC transporter substrate-binding protein/permease	-
MNU35_RS05060 (MNU35_05065)	1046073..1046795	+	723	WP_002446766.1	amino acid ABC transporter ATP-binding protein	-
MNU35_RS05065 (MNU35_05070)	1047158..1048288	+	1131	WP_002476052.1	tRNA epoxyqueuosine(34) reductase QueG	-
MNU35_RS05070 (MNU35_05075)	1048285..1048755	+	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MNU35_RS05075 (MNU35_05080)	1048913..1049512	+	600	WP_002446763.1	glucosamine-6-phosphate isomerase	Antitoxin
MNU35_RS05080 (MNU35_05085)	1049536..1049718	+	183	WP_002457885.1	SAS053 family protein	Toxin
MNU35_RS05085 (MNU35_05090)	1049849..1051165	-	1317	WP_002486577.1	ISL3 family transposase	-
MNU35_RS05090 (MNU35_05095)	1051366..1051770	+	405	WP_002446761.1	hypothetical protein	-
MNU35_RS05095 (MNU35_05100)	1051962..1053347	+	1386	WP_002447846.1	class II fumarate hydratase	-
MNU35_RS05100 (MNU35_05105)	1053822..1054304	+	483	Protein_971	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7080.67 Da
• Isoelectric Point: 4.3016

>T237744 WP_002457885.1 NZ_CP093170:1049536-1049718 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T237744 NZ_LR882500:c2233638-2233078 [Mycobacterium tuberculosis variant microti]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22635.54 Da
• Isoelectric Point: 4.9942

>AT237744 WP_002446763.1 NZ_CP093170:1048913-1049512 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT237744 NZ_LR882500:c2233976-2233635 [Mycobacterium tuberculosis variant microti]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E1VBD1