237742

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 878630..879139 Replicon chromosome
Accession NZ_CP093170
Organism Staphylococcus epidermidis strain TMDU-128

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag MNU35_RS04105 Protein ID WP_002447767.1
Coordinates 878930..879139 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag MNU35_RS04100 Protein ID WP_002458700.1
Coordinates 878630..878923 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU35_RS04075 (MNU35_04080) 873637..874425 + 789 WP_002475462.1 hydroxyethylthiazole kinase -
MNU35_RS04080 (MNU35_04085) 874431..875069 + 639 WP_002458704.1 thiamine phosphate synthase -
MNU35_RS04085 (MNU35_04090) 875158..876030 + 873 WP_002458703.1 membrane protein insertase YidC -
MNU35_RS04090 (MNU35_04095) 876137..876790 - 654 WP_002496981.1 HD domain-containing protein -
MNU35_RS04095 (MNU35_04100) 876972..878456 - 1485 WP_002447769.1 cardiolipin synthase -
MNU35_RS04100 (MNU35_04105) 878630..878923 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU35_RS04105 (MNU35_04110) 878930..879139 + 210 WP_002447767.1 cation transporter Toxin
MNU35_RS04110 (MNU35_04115) 879283..879420 + 138 WP_001829949.1 Lmo0850 family protein -
MNU35_RS04115 (MNU35_04120) 879519..880730 - 1212 WP_002447766.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU35_RS04120 (MNU35_04125) 881121..882194 + 1074 WP_002458698.1 D-alanine--D-alanine ligase -
MNU35_RS04125 (MNU35_04130) 882206..883561 + 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T237742 WP_002447767.1 NZ_CP093170:878930-879139 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T237742 NZ_LR882500:c2217549-2217253 [Mycobacterium tuberculosis variant microti]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT237742 WP_002458700.1 NZ_CP093170:878630-878923 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237742 NZ_LR882500:c2217797-2217546 [Mycobacterium tuberculosis variant microti]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References