Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1936720..1937190 | Replicon | chromosome |
| Accession | NZ_CP093165 | ||
| Organism | Staphylococcus epidermidis strain TMDU-41 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | MNU56_RS09120 | Protein ID | WP_001829569.1 |
| Coordinates | 1937002..1937190 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | MNU56_RS09115 | Protein ID | WP_002438963.1 |
| Coordinates | 1936720..1936977 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU56_RS09080 (MNU56_09065) | 1932007..1932144 | - | 138 | WP_162161215.1 | hypothetical protein | - |
| MNU56_RS09085 (MNU56_09070) | 1932174..1932361 | - | 188 | Protein_1755 | hypothetical protein | - |
| MNU56_RS09090 (MNU56_09075) | 1932512..1933690 | - | 1179 | WP_104832443.1 | IS110 family transposase | - |
| MNU56_RS09095 (MNU56_09080) | 1934308..1934808 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| MNU56_RS09100 (MNU56_09085) | 1935079..1935666 | - | 588 | WP_002469329.1 | histidine phosphatase family protein | - |
| MNU56_RS09105 (MNU56_09090) | 1935880..1936116 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| MNU56_RS09110 (MNU56_09095) | 1936108..1936311 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| MNU56_RS09115 (MNU56_09100) | 1936720..1936977 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| MNU56_RS09120 (MNU56_09105) | 1937002..1937190 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| MNU56_RS09125 (MNU56_09110) | 1937380..1937934 | + | 555 | WP_002469327.1 | lipoprotein N-acylation protein LnsA | - |
| MNU56_RS09130 (MNU56_09115) | 1937994..1938227 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| MNU56_RS09135 (MNU56_09120) | 1938511..1939257 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| MNU56_RS09140 (MNU56_09125) | 1939356..1939640 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| MNU56_RS09145 (MNU56_09130) | 1939664..1939888 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| MNU56_RS09150 (MNU56_09135) | 1940509..1940709 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1941721..1942794 | 1073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T237741 WP_001829569.1 NZ_CP093165:1937002-1937190 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T237741 NZ_LR882500:2215291-2215668 [Mycobacterium tuberculosis variant microti]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT237741 WP_002438963.1 NZ_CP093165:1936720-1936977 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT237741 NZ_LR882500:2215710-2216159 [Mycobacterium tuberculosis variant microti]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |