Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 828656..829185 Replicon chromosome
Accession NZ_CP093165
Organism Staphylococcus epidermidis strain TMDU-41

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MNU56_RS03840 Protein ID WP_001829891.1
Coordinates 828823..829185 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MNU56_RS03835 Protein ID WP_001829931.1
Coordinates 828656..828826 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU56_RS03810 (MNU56_03805) 824480..824959 + 480 WP_002457111.1 PH domain-containing protein -
MNU56_RS03815 (MNU56_03810) 824952..826457 + 1506 WP_002457110.1 PH domain-containing protein -
MNU56_RS03820 (MNU56_03815) 826444..826953 + 510 WP_002457109.1 PH domain-containing protein -
MNU56_RS03825 (MNU56_03820) 827001..827354 + 354 WP_002457108.1 holo-ACP synthase -
MNU56_RS03830 (MNU56_03825) 827421..828569 + 1149 WP_002457107.1 alanine racemase -
MNU56_RS03835 (MNU56_03830) 828656..828826 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MNU56_RS03840 (MNU56_03835) 828823..829185 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU56_RS03845 (MNU56_03840) 829530..830531 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MNU56_RS03850 (MNU56_03845) 830631..830957 + 327 WP_001829952.1 anti-sigma factor antagonist -
MNU56_RS03855 (MNU56_03850) 830959..831432 + 474 WP_002469585.1 anti-sigma B factor RsbW -
MNU56_RS03860 (MNU56_03855) 831407..832177 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T237739 WP_001829891.1 NZ_CP093165:828823-829185 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T237739 NZ_LR882500:1970080-1970328 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT237739 WP_001829931.1 NZ_CP093165:828656-828826 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT237739 NZ_LR882500:1969868-1970080 [Mycobacterium tuberculosis variant microti]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References