Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 817471..817980 Replicon chromosome
Accession NZ_CP093165
Organism Staphylococcus epidermidis strain TMDU-41

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MNU56_RS03780 Protein ID WP_001829980.1
Coordinates 817771..817980 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MNU56_RS03775 Protein ID WP_001829893.1
Coordinates 817471..817764 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU56_RS03750 (MNU56_03745) 812479..813267 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MNU56_RS03755 (MNU56_03750) 813273..813911 + 639 WP_002505076.1 thiamine phosphate synthase -
MNU56_RS03760 (MNU56_03755) 814000..814872 + 873 WP_002470121.1 membrane protein insertase YidC -
MNU56_RS03765 (MNU56_03760) 814978..815631 - 654 WP_001829983.1 HD domain-containing protein -
MNU56_RS03770 (MNU56_03765) 815813..817297 - 1485 WP_002457116.1 cardiolipin synthase -
MNU56_RS03775 (MNU56_03770) 817471..817764 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MNU56_RS03780 (MNU56_03775) 817771..817980 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MNU56_RS03785 (MNU56_03780) 818123..818260 + 138 WP_001829949.1 Lmo0850 family protein -
MNU56_RS03790 (MNU56_03785) 818359..819570 - 1212 WP_002457115.1 FtsW/RodA/SpoVE family cell cycle protein -
MNU56_RS03795 (MNU56_03790) 819961..821034 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MNU56_RS03800 (MNU56_03795) 821046..822401 + 1356 WP_254104114.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T237738 WP_001829980.1 NZ_CP093165:817771-817980 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T237738 NZ_LR882500:c1949525-1949136 [Mycobacterium tuberculosis variant microti]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTATCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT237738 WP_001829893.1 NZ_CP093165:817471-817764 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT237738 NZ_LR882500:c1949749-1949522 [Mycobacterium tuberculosis variant microti]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References