Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 45948..46585 | Replicon | plasmid pECLA |
Accession | NZ_CP093155 | ||
Organism | Enterobacter asburiae strain 5549 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A9E6WXZ4 |
Locus tag | MND42_RS23525 | Protein ID | WP_032662169.1 |
Coordinates | 45948..46358 (-) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A9E6WTF5 |
Locus tag | MND42_RS23530 | Protein ID | WP_032662167.1 |
Coordinates | 46355..46585 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MND42_RS23505 (MND42_23505) | 41378..42358 | + | 981 | WP_000019445.1 | IS5-like element ISKpn26 family transposase | - |
MND42_RS23510 (MND42_23510) | 42501..42761 | - | 261 | Protein_43 | HNH endonuclease | - |
MND42_RS23515 (MND42_23515) | 43305..44327 | - | 1023 | WP_032662174.1 | helicase UvrD | - |
MND42_RS23520 (MND42_23520) | 44312..45874 | - | 1563 | WP_032662171.1 | AAA family ATPase | - |
MND42_RS23525 (MND42_23525) | 45948..46358 | - | 411 | WP_032662169.1 | PIN domain-containing protein | Toxin |
MND42_RS23530 (MND42_23530) | 46355..46585 | - | 231 | WP_032662167.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MND42_RS23535 (MND42_23535) | 47127..47417 | + | 291 | WP_013087126.1 | hypothetical protein | - |
MND42_RS23540 (MND42_23540) | 47548..48078 | + | 531 | WP_241510746.1 | hypothetical protein | - |
MND42_RS23545 (MND42_23545) | 48097..48873 | + | 777 | WP_015572054.1 | site-specific integrase | - |
MND42_RS23550 (MND42_23550) | 49075..49332 | + | 258 | Protein_51 | site-specific integrase | - |
MND42_RS23555 (MND42_23555) | 49576..50586 | - | 1011 | WP_015572055.1 | RepB family plasmid replication initiator protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-10 | galE | 1..159417 | 159417 | |
- | flank | IS/Tn | - | - | 41378..42358 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14729.03 Da Isoelectric Point: 5.7351
>T237737 WP_032662169.1 NZ_CP093155:c46358-45948 [Enterobacter asburiae]
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWAEVSLASQEAGPAAQKLADAFAARLDAILPWDRTAV
DATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWAEVSLASQEAGPAAQKLADAFAARLDAILPWDRTAV
DATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR
Download Length: 411 bp
>T237737 NZ_LR882500:1776190-1776594 [Mycobacterium tuberculosis variant microti]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8645.77 Da Isoelectric Point: 4.4692
>AT237737 WP_032662167.1 NZ_CP093155:c46585-46355 [Enterobacter asburiae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRVNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRVNL
Download Length: 231 bp
>AT237737 NZ_LR882500:1775981-1776184 [Mycobacterium tuberculosis variant microti]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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