Detailed information of TA system TA237735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4234654..4235170
• Replicon: chromosome
• Accession: NZ_CP093154
• Organism: Enterobacter asburiae strain 5549

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MND42_RS20490
• Protein ID: WP_045402335.1
• Coordinates: 4234654..4234938 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: MND42_RS20495
• Protein ID: WP_008501400.1
• Coordinates: 4234928..4235170 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MND42_RS20475 (MND42_20475)	4229880..4231523	+	1644	WP_241510616.1	alpha,alpha-phosphotrehalase	-
MND42_RS20480 (MND42_20480)	4231900..4234038	+	2139	WP_045402340.1	anaerobic ribonucleoside-triphosphate reductase	-
MND42_RS20485 (MND42_20485)	4234186..4234650	+	465	WP_045402338.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MND42_RS20490 (MND42_20490)	4234654..4234938	-	285	WP_045402335.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MND42_RS20495 (MND42_20495)	4234928..4235170	-	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MND42_RS20500 (MND42_20500)	4235248..4237158	-	1911	WP_023310188.1	PRD domain-containing protein	-
MND42_RS20505 (MND42_20505)	4237181..4238317	-	1137	WP_045402331.1	lactonase family protein	-
MND42_RS20510 (MND42_20510)	4238433..4239173	-	741	WP_045355655.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10907.73 Da
• Isoelectric Point: 10.3350

>T237735 WP_045402335.1 NZ_CP093154:c4234938-4234654 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T237735 NZ_LR882500:c1582983-1582582 [Mycobacterium tuberculosis variant microti]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT237735 WP_008501400.1 NZ_CP093154:c4235170-4234928 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT237735 NZ_LR882500:c1583237-1582980 [Mycobacterium tuberculosis variant microti]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3