Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3799639..3800354 Replicon chromosome
Accession NZ_CP093154
Organism Enterobacter asburiae strain 5549

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag MND42_RS18435 Protein ID WP_023303149.1
Coordinates 3799639..3800007 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag MND42_RS18440 Protein ID WP_023303148.1
Coordinates 3800028..3800354 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MND42_RS18420 (MND42_18420) 3796738..3797298 - 561 WP_052671746.1 fimbrial protein -
MND42_RS18425 (MND42_18425) 3797365..3797886 - 522 WP_045400550.1 fimbrial protein -
MND42_RS18430 (MND42_18430) 3798607..3799197 + 591 WP_045400548.1 winged helix-turn-helix transcriptional regulator -
MND42_RS18435 (MND42_18435) 3799639..3800007 - 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
MND42_RS18440 (MND42_18440) 3800028..3800354 - 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MND42_RS18445 (MND42_18445) 3800367..3800837 - 471 WP_023303147.1 DNA repair protein RadC -
MND42_RS18450 (MND42_18450) 3800903..3801724 - 822 WP_023303146.1 DUF932 domain-containing protein -
MND42_RS24590 3801780..3801902 + 123 WP_255740893.1 hypothetical protein -
MND42_RS18455 (MND42_18455) 3802414..3803253 - 840 WP_023303145.1 hypothetical protein -
MND42_RS18460 (MND42_18460) 3803312..3803746 - 435 WP_023303144.1 hypothetical protein -
MND42_RS18465 (MND42_18465) 3804055..3805320 - 1266 WP_023303143.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3786129..3821272 35143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T237734 WP_023303149.1 NZ_CP093154:c3800007-3799639 [Enterobacter asburiae]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

>T237734 NZ_LR882500:1548217-1549038 [Mycobacterium tuberculosis variant microti]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT237734 WP_023303148.1 NZ_CP093154:c3800354-3800028 [Enterobacter asburiae]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp

>AT237734 NZ_LR882500:1549031-1549267 [Mycobacterium tuberculosis variant microti]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References