Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3660833..3661453 Replicon chromosome
Accession NZ_CP093154
Organism Enterobacter asburiae strain 5549

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag MND42_RS17775 Protein ID WP_008499287.1
Coordinates 3661235..3661453 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag MND42_RS17770 Protein ID WP_008499288.1
Coordinates 3660833..3661207 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MND42_RS17760 (MND42_17760) 3655959..3657152 + 1194 WP_023310601.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MND42_RS17765 (MND42_17765) 3657175..3660321 + 3147 WP_023310600.1 multidrug efflux RND transporter permease subunit AcrB -
MND42_RS17770 (MND42_17770) 3660833..3661207 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
MND42_RS17775 (MND42_17775) 3661235..3661453 + 219 WP_008499287.1 HHA domain-containing protein Toxin
MND42_RS17780 (MND42_17780) 3661659..3662210 + 552 WP_023310599.1 maltose O-acetyltransferase -
MND42_RS17785 (MND42_17785) 3662328..3662795 + 468 WP_045400719.1 YlaC family protein -
MND42_RS17790 (MND42_17790) 3662767..3664227 - 1461 WP_045400715.1 PLP-dependent aminotransferase family protein -
MND42_RS17795 (MND42_17795) 3664329..3665039 + 711 WP_023310596.1 GNAT family protein -
MND42_RS17800 (MND42_17800) 3665036..3665176 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MND42_RS17805 (MND42_17805) 3665179..3665439 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T237733 WP_008499287.1 NZ_CP093154:3661235-3661453 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T237733 NZ_LR882500:c1392672-1392379 [Mycobacterium tuberculosis variant microti]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT237733 WP_008499288.1 NZ_CP093154:3660833-3661207 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT237733 NZ_LR882500:c1392938-1392669 [Mycobacterium tuberculosis variant microti]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References