Detailed information of TA system TA237722

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 860841..861498
• Replicon: chromosome
• Accession: NZ_CP093154
• Organism: Enterobacter asburiae strain 5549

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MND42_RS04200
• Protein ID: WP_045405042.1
• Coordinates: 861088..861498 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: MND42_RS04195
• Protein ID: WP_010435322.1
• Coordinates: 860841..861107 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MND42_RS04170 (MND42_04170)	856023..857456	-	1434	WP_045405037.1	6-phospho-beta-glucosidase BglA	-
MND42_RS04175 (MND42_04175)	857573..858304	-	732	WP_032660101.1	MurR/RpiR family transcriptional regulator	-
MND42_RS04180 (MND42_04180)	858356..858667	+	312	WP_023309102.1	N(4)-acetylcytidine aminohydrolase	-
MND42_RS04185 (MND42_04185)	858833..859492	+	660	WP_023309101.1	hemolysin III family protein	-
MND42_RS04190 (MND42_04190)	859566..860546	-	981	WP_045405040.1	tRNA-modifying protein YgfZ	-
MND42_RS04195 (MND42_04195)	860841..861107	+	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
MND42_RS04200 (MND42_04200)	861088..861498	+	411	WP_045405042.1	protein YgfX	Toxin
MND42_RS04205 (MND42_04205)	861505..862026	-	522	WP_045405044.1	flavodoxin FldB	-
MND42_RS04210 (MND42_04210)	862128..863024	+	897	WP_023309098.1	site-specific tyrosine recombinase XerD	-
MND42_RS04215 (MND42_04215)	863053..863766	+	714	WP_045405046.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MND42_RS04220 (MND42_04220)	863772..865505	+	1734	WP_045355605.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16157.12 Da
• Isoelectric Point: 10.9865

>T237722 WP_045405042.1 NZ_CP093154:861088-861498 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNYGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T237722 NZ_LR882500:719802-720209 [Mycobacterium tuberculosis variant microti]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT237722 WP_010435322.1 NZ_CP093154:860841-861107 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT237722 NZ_LR882500:719545-719805 [Mycobacterium tuberculosis variant microti]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Antitoxin

• AlphaFold DB: V3PWU7