Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4135382..4136001 Replicon chromosome
Accession NZ_CP093151
Organism Klebsiella pneumoniae strain CY814036

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MMZ10_RS20375 Protein ID WP_002892050.1
Coordinates 4135783..4136001 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MMZ10_RS20370 Protein ID WP_002892066.1
Coordinates 4135382..4135756 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ10_RS20360 (4130534) 4130534..4131727 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MMZ10_RS20365 (4131750) 4131750..4134896 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MMZ10_RS20370 (4135382) 4135382..4135756 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MMZ10_RS20375 (4135783) 4135783..4136001 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MMZ10_RS20380 (4136160) 4136160..4136726 + 567 WP_002892030.1 maltose O-acetyltransferase -
MMZ10_RS20385 (4136698) 4136698..4136838 - 141 WP_004147370.1 hypothetical protein -
MMZ10_RS20390 (4136859) 4136859..4137329 + 471 WP_002892026.1 YlaC family protein -
MMZ10_RS20395 (4137304) 4137304..4138755 - 1452 WP_032436946.1 PLP-dependent aminotransferase family protein -
MMZ10_RS20400 (4138856) 4138856..4139554 + 699 WP_002892021.1 GNAT family protein -
MMZ10_RS20405 (4139551) 4139551..4139691 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MMZ10_RS20410 (4139691) 4139691..4139954 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T237710 WP_002892050.1 NZ_CP093151:4135783-4136001 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T237710 NZ_LR882499:3803852-3804262 [Mycobacterium tuberculosis variant microti OV254]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT237710 WP_002892066.1 NZ_CP093151:4135382-4135756 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT237710 NZ_LR882499:3803577-3803855 [Mycobacterium tuberculosis variant microti OV254]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References