Detailed information of TA system TA023771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 715192..716171
• Replicon: chromosome
• Accession: NC_012632
• Organism: Sulfolobus islandicus M.16.27

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C4KFP3
• Locus tag: M1627_RS03720
• Protein ID: WP_012710837.1
• Coordinates: 715192..715806 (-)
• Length: 205 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C3MWA9
• Locus tag: M1627_RS03725
• Protein ID: WP_012710838.1
• Coordinates: 715824..716171 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1627_RS03685 (M1627_0745)	710438..711628	-	1191	WP_012710830.1	amidohydrolase family protein	-
M1627_RS15675 (M1627_0746)	711677..711876	-	200	Protein_755	hypothetical protein	-
M1627_RS03690 (M1627_0747)	711968..712567	-	600	WP_012710831.1	DUF2249 domain-containing protein	-
M1627_RS03695 (M1627_0748)	712816..713043	+	228	WP_012710832.1	hypothetical protein	-
M1627_RS03700 (M1627_0749)	713024..713347	-	324	WP_012710833.1	hypothetical protein	-
M1627_RS03705 (M1627_0750)	713351..714115	-	765	WP_012710834.1	plastocyanin/azurin family copper-binding protein	-
M1627_RS03710 (M1627_0751)	714220..714747	-	528	WP_012710835.1	hemerythrin domain-containing protein	-
M1627_RS03715 (M1627_0752)	714872..715147	+	276	WP_012710836.1	hypothetical protein	-
M1627_RS03720 (M1627_0753)	715192..715806	-	615	WP_012710837.1	helix-turn-helix domain-containing protein	Toxin
M1627_RS03725 (M1627_0754)	715824..716171	-	348	WP_012710838.1	DUF488 domain-containing protein	Antitoxin
M1627_RS03730	716240..716470	-	231	WP_012735723.1	C2H2-type zinc finger protein	-
M1627_RS14610	716540..716949	+	410	Protein_765	IS630 family transposase	-
M1627_RS03735 (M1627_0757)	717292..717780	+	489	WP_016730613.1	nucleotidyltransferase domain-containing protein	-
M1627_RS03740	717770..717994	+	225	WP_016730614.1	HEPN domain-containing protein	-
M1627_RS03745	717995..718207	+	213	WP_016730615.1	HEPN domain-containing protein	-
M1627_RS03750 (M1627_0759)	718704..719087	+	384	WP_016730616.1	metal-sulfur cluster assembly factor	-
M1627_RS03755 (M1627_0760)	719080..719511	-	432	WP_012710841.1	universal stress protein	-
M1627_RS03760 (M1627_0761)	719972..720910	-	939	WP_012710842.1	dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (145-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 205 a.a.
• Molecular weight: 23169.24 Da
• Isoelectric Point: 9.5043

>T23771 WP_012710837.1 NC_012632:c715806-715192 [Sulfolobus islandicus M.16.27]
MLKSPFEVTILIEDHPCEVMRIISSTGLKATVGNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSVKVLKLNDSKVWVRTN
GCSVCKILYTSNVVIEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQGIKFTVLSTSEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISAPTLEEIMRRALRKVVKYYLDKVG

Nucleotide

• Length: 615 bp

>T23771 NC_012632:c715806-715192 [Sulfolobus islandicus M.16.27]
ATGTTAAAATCACCATTCGAAGTAACAATCTTGATTGAAGATCATCCTTGTGAGGTTATGAGGATAATATCTAGTACTGG
GCTTAAAGCAACCGTTGGCAACGTTAAACTCGGCGATAATACAACTGATCACATAGTCCTTTTCGAAAAAGAGGTTCAAA
AAGATGATCTGATTAAACTTAAGTCCCATAGTGTCAAAGTCTTAAAGCTTAATGATAGCAAAGTATGGGTTAGAACTAAT
GGATGCTCAGTATGTAAGATTCTCTATACTTCAAATGTTGTCATAGAGAAAATAAAAGTAATAAAAGAGAGAACATTACT
CTATACGCTTTTGGTCCCTAATACGATAGCTTTTAAGGAGTTTCTAGCTAATCTTACTAGTCAAGGGATAAAGTTTACAG
TCCTAAGCACCTCTGAAATAAGCAGTAATGACTTAACTGATAGACAAATGGAAATATTGAAACTTGCATACAAGATGGGT
TATTTTGATGATGATAGGAGGGTAACTTTAACTGAATTAGCAAAGCAATTGGGAATATCAGCTCCGACTTTGGAGGAAAT
TATGAGGAGAGCGTTAAGGAAAGTCGTCAAGTATTATTTAGACAAAGTAGGGTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13731.06 Da
• Isoelectric Point: 9.9999

>AT23771 WP_012710838.1 NC_012632:c716171-715824 [Sulfolobus islandicus M.16.27]
MIKIKRVYDPIEKDDGIRILVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDPNKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Nucleotide

• Length: 348 bp

>AT23771 NC_012632:c716171-715824 [Sulfolobus islandicus M.16.27]
ATGATTAAGATAAAGAGGGTTTACGATCCAATAGAGAAAGATGACGGAATAAGAATCTTAGTGGATAGGTTATGGCCAAG
AGGAATTGGTAAAAATAAGGTAGATTTATGGCTTAAAGATATAGCACCTAGTGATGAGTTACGAAAATGGTACGGTCATG
ATCCTAATAAATGGGATGAGTTCAAAAGGAAATATTTTGAGGAACTAGATGCTAATCCAAAGATGAGCATTTTATTACAA
TTAATTAGAAAGGGCGAAAATATTACCTTACTTTACGCCTCCAAATCACCGTATAATAATGCGGTTGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Structures

Toxin

• AlphaFold DB: C4KFP3

Antitoxin

• AlphaFold DB: C3MWA9