Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 1817868..1818511 | Replicon | chromosome |
| Accession | NZ_CP093151 | ||
| Organism | Klebsiella pneumoniae strain CY814036 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A4GZE5 |
| Locus tag | MMZ10_RS08730 | Protein ID | WP_015874977.1 |
| Coordinates | 1817868..1818284 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A4GZE4 |
| Locus tag | MMZ10_RS08735 | Protein ID | WP_015874976.1 |
| Coordinates | 1818281..1818511 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMZ10_RS08710 (1813271) | 1813271..1814386 | - | 1116 | WP_032447702.1 | salmochelin biosynthesis C-glycosyltransferase IroB | - |
| MMZ10_RS08715 (1814559) | 1814559..1814837 | - | 279 | Protein_1703 | ISNCY family transposase | - |
| MMZ10_RS08720 (1815258) | 1815258..1817432 | + | 2175 | WP_015874979.1 | siderophore salmochelin receptor IroN | - |
| MMZ10_RS08725 (1817587) | 1817587..1817832 | - | 246 | WP_032447699.1 | hypothetical protein | - |
| MMZ10_RS08730 (1817868) | 1817868..1818284 | - | 417 | WP_015874977.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MMZ10_RS08735 (1818281) | 1818281..1818511 | - | 231 | WP_015874976.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MMZ10_RS08740 (1819005) | 1819005..1819334 | + | 330 | WP_225315331.1 | hypothetical protein | - |
| MMZ10_RS08745 (1819522) | 1819522..1820492 | + | 971 | Protein_1709 | IS21-like element IS100 family transposase | - |
| MMZ10_RS08750 (1820519) | 1820519..1821245 | + | 727 | Protein_1710 | IS21-like element helper ATPase IstB | - |
| MMZ10_RS08755 (1821289) | 1821289..1821402 | - | 114 | WP_015874970.1 | Hha/YmoA family nucleoid-associated regulatory protein | - |
| MMZ10_RS08760 (1821645) | 1821645..1821854 | - | 210 | WP_032447696.1 | TraR/DksA family transcriptional regulator | - |
| MMZ10_RS08765 (1821844) | 1821844..1822425 | - | 582 | WP_000937857.1 | DUF2857 domain-containing protein | - |
| MMZ10_RS08770 (1822410) | 1822410..1822592 | - | 183 | WP_072001695.1 | hypothetical protein | - |
| MMZ10_RS08775 (1822614) | 1822614..1822799 | - | 186 | WP_000205185.1 | AlpA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rmpA / iroD / iroC / iroB / iroN / fyuA / ybtE / ybtT / ybtU | 1774731..1838187 | 63456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14945.39 Da Isoelectric Point: 8.5464
>T237700 WP_015874977.1 NZ_CP093151:c1818284-1817868 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAGLRGDRIVVSAVTYAEMRFGATGPKASPHHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAGLRGDRIVVSAVTYAEMRFGATGPKASPHHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T237700 NZ_LR882499:c3065949-3065554 [Mycobacterium tuberculosis variant microti OV254]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8749.80 Da Isoelectric Point: 4.3533
>AT237700 WP_015874976.1 NZ_CP093151:c1818511-1818281 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMVEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMVEREDVVSDEGRFEP
Download Length: 231 bp
>AT237700 NZ_LR882499:c3065528-3065262 [Mycobacterium tuberculosis variant microti OV254]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|