Detailed information of TA system TA023770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 372719..373325
• Replicon: chromosome
• Accession: NC_012632
• Organism: Sulfolobus islandicus M.16.27

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C4KDU4
• Locus tag: M1627_RS02090
• Protein ID: WP_012718409.1
• Coordinates: 372719..373081 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UCL5
• Locus tag: M1627_RS02095
• Protein ID: WP_012718013.1
• Coordinates: 373104..373325 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1627_RS02075 (M1627_0410)	368535..369932	-	1398	WP_012718408.1	glycosyltransferase	-
M1627_RS02080 (M1627_0411)	369977..370570	-	594	WP_012710546.1	hypothetical protein	-
M1627_RS02085 (M1627_0412)	370662..372215	+	1554	WP_012710547.1	aldehyde dehydrogenase family protein	-
M1627_RS15285	372267..372437	-	171	WP_175282303.1	hypothetical protein	-
M1627_RS02090 (M1627_0413)	372719..373081	-	363	WP_012718409.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1627_RS02095 (M1627_0414)	373104..373325	-	222	WP_012718013.1	hypothetical protein	Antitoxin
M1627_RS02100 (M1627_0416)	374606..375139	-	534	WP_012710551.1	ADP-ribose-binding protein	-
M1627_RS02105 (M1627_0417)	375294..376439	+	1146	WP_012718410.1	glycosyltransferase family 4 protein	-
M1627_RS02110 (M1627_0418)	376444..377004	+	561	WP_012710553.1	PIG-L deacetylase family protein	-
M1627_RS02115 (M1627_0419)	377008..377445	+	438	WP_012710554.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (21-113)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13845.22 Da
• Isoelectric Point: 8.3217

>T23770 WP_012718409.1 NC_012632:c373081-372719 [Sulfolobus islandicus M.16.27]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIME
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Nucleotide

• Length: 363 bp

>T23770 NC_012632:c373081-372719 [Sulfolobus islandicus M.16.27]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAATGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8952.22 Da
• Isoelectric Point: 4.6475

>AT23770 WP_012718013.1 NC_012632:c373325-373104 [Sulfolobus islandicus M.16.27]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Nucleotide

• Length: 222 bp

>AT23770 NC_012632:c373325-373104 [Sulfolobus islandicus M.16.27]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Structures

Toxin

• AlphaFold DB: C4KDU4

Antitoxin

• AlphaFold DB: M9UCL5