Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812592..813249 Replicon chromosome
Accession NZ_CP093151
Organism Klebsiella pneumoniae strain CY814036

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MMZ10_RS04025 Protein ID WP_002916310.1
Coordinates 812839..813249 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MMZ10_RS04020 Protein ID WP_002916312.1
Coordinates 812592..812858 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ10_RS03995 (807800) 807800..809233 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MMZ10_RS04000 (809352) 809352..810080 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MMZ10_RS04005 (810130) 810130..810441 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MMZ10_RS04010 (810605) 810605..811264 + 660 WP_002916317.1 hemolysin III family protein -
MMZ10_RS04015 (811363) 811363..812346 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MMZ10_RS04020 (812592) 812592..812858 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MMZ10_RS04025 (812839) 812839..813249 + 411 WP_002916310.1 protein YgfX Toxin
MMZ10_RS04030 (813256) 813256..813777 - 522 WP_004144730.1 flavodoxin FldB -
MMZ10_RS04035 (813878) 813878..814774 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MMZ10_RS04040 (814797) 814797..815510 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MMZ10_RS04045 (815516) 815516..817249 + 1734 WP_241510768.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T237699 WP_002916310.1 NZ_CP093151:812839-813249 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T237699 NZ_LR882499:c3065265-3064849 [Mycobacterium tuberculosis variant microti OV254]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237699 WP_002916312.1 NZ_CP093151:812592-812858 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237699 NZ_LR882499:c3065528-3065262 [Mycobacterium tuberculosis variant microti OV254]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References