Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 541026..541662 | Replicon | chromosome |
| Accession | NZ_CP093150 | ||
| Organism | Bacillus altitudinis strain JYY-02 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | K2MHT4 |
| Locus tag | MMZ59_RS02610 | Protein ID | WP_003214169.1 |
| Coordinates | 541312..541662 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | W8QJ31 |
| Locus tag | MMZ59_RS02605 | Protein ID | WP_003214273.1 |
| Coordinates | 541026..541307 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMZ59_RS02585 (MMZ59_02585) | 537180..537785 | - | 606 | WP_007496491.1 | rhomboid family intramembrane serine protease | - |
| MMZ59_RS02590 (MMZ59_02590) | 537880..538245 | + | 366 | WP_017358398.1 | holo-ACP synthase | - |
| MMZ59_RS02595 (MMZ59_02595) | 538406..539422 | + | 1017 | WP_007496489.1 | outer membrane lipoprotein-sorting protein | - |
| MMZ59_RS02600 (MMZ59_02600) | 539551..540732 | + | 1182 | WP_241511749.1 | alanine racemase | - |
| MMZ59_RS02605 (MMZ59_02605) | 541026..541307 | + | 282 | WP_003214273.1 | hypothetical protein | Antitoxin |
| MMZ59_RS02610 (MMZ59_02610) | 541312..541662 | + | 351 | WP_003214169.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| MMZ59_RS02615 (MMZ59_02615) | 541777..542607 | + | 831 | WP_017358395.1 | RsbT co-antagonist protein RsbRA | - |
| MMZ59_RS02620 (MMZ59_02620) | 542612..542980 | + | 369 | WP_003214235.1 | RsbT antagonist protein RsbS | - |
| MMZ59_RS02625 (MMZ59_02625) | 542983..543384 | + | 402 | WP_003214085.1 | anti-sigma regulatory factor | - |
| MMZ59_RS02630 (MMZ59_02630) | 543395..544402 | + | 1008 | WP_008346904.1 | PP2C family protein-serine/threonine phosphatase | - |
| MMZ59_RS02635 (MMZ59_02635) | 544462..544791 | + | 330 | WP_008346902.1 | anti-sigma factor antagonist | - |
| MMZ59_RS02640 (MMZ59_02640) | 544788..545276 | + | 489 | WP_007496471.1 | anti-sigma B factor RsbW | - |
| MMZ59_RS02645 (MMZ59_02645) | 545242..546030 | + | 789 | WP_025206796.1 | RNA polymerase sigma factor SigB | - |
| MMZ59_RS02650 (MMZ59_02650) | 546030..546629 | + | 600 | WP_017358391.1 | PP2C family serine/threonine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12976.99 Da Isoelectric Point: 5.1663
>T237696 WP_003214169.1 NZ_CP093150:541312-541662 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF
Download Length: 351 bp
>T237696 NZ_LR882499:c2866160-2865765 [Mycobacterium tuberculosis variant microti OV254]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10864.25 Da Isoelectric Point: 5.2726
>AT237696 WP_003214273.1 NZ_CP093150:541026-541307 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG
Download Length: 282 bp
>AT237696 NZ_LR882499:c2866402-2866157 [Mycobacterium tuberculosis variant microti OV254]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | K2MHT4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A081L854 |