Detailed information of TA system TA023769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2334556..2335162
• Replicon: chromosome
• Accession: NC_012623
• Organism: Sulfolobus islandicus Y.N.15.51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C3NLK1
• Locus tag: YN1551_RS12615
• Protein ID: WP_012718014.1
• Coordinates: 2334800..2335162 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UCL5
• Locus tag: YN1551_RS12610
• Protein ID: WP_012718013.1
• Coordinates: 2334556..2334777 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YN1551_RS12570 (YN1551_2621)	2330242..2330592	+	351	WP_187146895.1	hypothetical protein	-
YN1551_RS12575 (YN1551_2622)	2330700..2330987	+	288	WP_012718008.1	hypothetical protein	-
YN1551_RS12580 (YN1551_2623)	2330948..2331496	+	549	WP_012718009.1	hypothetical protein	-
YN1551_RS12585 (YN1551_2624)	2331538..2331894	-	357	WP_238527849.1	hypothetical protein	-
YN1551_RS16245 (YN1551_2625)	2332033..2332347	+	315	Protein_2588	transposase	-
YN1551_RS12595 (YN1551_2626)	2332388..2332852	+	465	WP_274379013.1	GTP-binding protein	-
YN1551_RS12600 (YN1551_2627)	2332849..2333445	+	597	WP_012718011.1	urease accessory protein UreD	-
YN1551_RS17915 (YN1551_2628)	2333492..2333626	+	135	WP_012718012.1	hypothetical protein	-
YN1551_RS12610 (YN1551_2630)	2334556..2334777	+	222	WP_012718013.1	hypothetical protein	Antitoxin
YN1551_RS12615 (YN1551_2631)	2334800..2335162	+	363	WP_012718014.1	type II toxin-antitoxin system VapC family toxin	Toxin
YN1551_RS12620 (YN1551_2633)	2335450..2336578	-	1129	Protein_2594	RNA-guided endonuclease TnpB family protein	-
YN1551_RS12625 (YN1551_2634)	2337121..2338188	-	1068	Protein_2595	IS110 family transposase	-
YN1551_RS12630 (YN1551_2635)	2338473..2340026	-	1554	WP_012718016.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2330242..2338263	8021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (21-113)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13886.26 Da
• Isoelectric Point: 9.2430

>T23769 WP_012718014.1 NC_012623:2334800-2335162 [Sulfolobus islandicus Y.N.15.51]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITLQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Nucleotide

• Length: 363 bp

>T23769 NC_012623:2334800-2335162 [Sulfolobus islandicus Y.N.15.51]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCTACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8952.22 Da
• Isoelectric Point: 4.6475

>AT23769 WP_012718013.1 NC_012623:2334556-2334777 [Sulfolobus islandicus Y.N.15.51]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Nucleotide

• Length: 222 bp

>AT23769 NC_012623:2334556-2334777 [Sulfolobus islandicus Y.N.15.51]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTAGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Structures

Toxin

• AlphaFold DB: C3NLK1

Antitoxin

• AlphaFold DB: M9UCL5