Detailed information of TA system TA023768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1937044..1937607
• Replicon: chromosome
• Accession: NC_012623
• Organism: Sulfolobus islandicus Y.N.15.51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: YN1551_RS17595
• Protein ID: WP_238527822.1
• Coordinates: 1937044..1937220 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: YN1551_RS10575
• Protein ID: WP_187146859.1
• Coordinates: 1937347..1937607 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YN1551_RS17585	1932119..1932277	+	159	WP_238527821.1	hypothetical protein	-
YN1551_RS17590 (YN1551_2165)	1932914..1933090	-	177	WP_012717772.1	hypothetical protein	-
YN1551_RS10550 (YN1551_2166)	1933253..1934344	-	1092	WP_012717773.1	hypothetical protein	-
YN1551_RS10555 (YN1551_2167)	1934562..1934960	+	399	WP_048052347.1	hypothetical protein	-
YN1551_RS10560 (YN1551_2168)	1935264..1935569	+	306	WP_012717775.1	heavy metal-binding domain-containing protein	-
YN1551_RS17110 (YN1551_2170)	1935786..1935950	+	165	WP_012717777.1	hypothetical protein	-
YN1551_RS10565 (YN1551_2171)	1935937..1937028	+	1092	WP_048052348.1	hypothetical protein	-
YN1551_RS17595	1937044..1937220	-	177	WP_238527822.1	PIN domain-containing protein	Toxin
YN1551_RS10575 (YN1551_2173)	1937347..1937607	-	261	WP_187146859.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YN1551_RS10580 (YN1551_2174)	1937984..1938220	+	237	WP_009991916.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
YN1551_RS10585 (YN1551_2175)	1938198..1938596	+	399	WP_009991918.1	type II toxin-antitoxin system VapC family toxin	-
YN1551_RS10590 (YN1551_2176)	1938719..1939453	-	735	WP_012717432.1	IS1-like element ISC796 family transposase	-
YN1551_RS16055 (YN1551_2178)	1939814..1939969	+	156	Protein_2161	DUF4322 domain-containing protein	-
YN1551_RS10595 (YN1551_2179)	1940254..1941487	-	1234	Protein_2162	IS256-like element ISC1332 family transposase	-
YN1551_RS10605 (YN1551_2180)	1941530..1941814	+	285	Protein_2163	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-53)

Antitoxin

• SpoVT-AbrB domain (4-46)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6877.07 Da
• Isoelectric Point: 9.3789

>T23768 WP_238527822.1 NC_012623:c1937220-1937044 [Sulfolobus islandicus Y.N.15.51]
VSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYERAKEIMRKYSVKPSDAIDNSFR

Nucleotide

• Length: 177 bp

>T23768 NC_012623:c1937220-1937044 [Sulfolobus islandicus Y.N.15.51]
GTGTCTAAGAAGAAGTATGGAGTTAAGTATTGCGATACCATAGAATTCTTGGATGAAATAGTGCTCAAGTACTTAACAGT
TTTACCAATCACGATAAAGGAATATGAGAGGGCTAAAGAAATTATGAGAAAATACTCAGTTAAGCCATCTGATGCCATTG
ACAACAGTTTCCGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9859.53 Da
• Isoelectric Point: 5.2739

>AT23768 WP_187146859.1 NC_012623:c1937607-1937347 [Sulfolobus islandicus Y.N.15.51]
MTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENISL
EEEFED

Nucleotide

• Length: 261 bp

>AT23768 NC_012623:c1937607-1937347 [Sulfolobus islandicus Y.N.15.51]
TTGACTCTAAGAGTGGAAGTTGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAATAAAAGA
GGGGGATATCTTAATTTTGACAGTCGTTGGAGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAGAAGTTG
TCAAAAAATTAGAAGAACATGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATAAGTCTT
GAAGAGGAATTTGAAGATTGA