Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3069363..3070181 Replicon chromosome
Accession NZ_CP093068
Organism Escherichia coli strain BR1220

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag MM431_RS15130 Protein ID WP_000771609.1
Coordinates 3069363..3069737 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag MM431_RS15135 Protein ID WP_001285568.1
Coordinates 3069828..3070181 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM431_RS15090 (3064367) 3064367..3064858 - 492 WP_001300785.1 DUF1097 domain-containing protein -
MM431_RS15095 (3064960) 3064960..3065514 - 555 WP_001001921.1 molecular chaperone YcdY -
MM431_RS15100 (3065538) 3065538..3066275 - 738 WP_000283667.1 zinc-binding phosphatase -
MM431_RS15105 (3066330) 3066330..3067268 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
MM431_RS15115 (3067739) 3067739..3068581 - 843 WP_001274560.1 DUF4942 domain-containing protein -
MM431_RS15120 (3068666) 3068666..3068863 - 198 WP_000839270.1 DUF957 domain-containing protein -
MM431_RS15125 (3068875) 3068875..3069366 - 492 WP_000976860.1 DUF5983 family protein -
MM431_RS15130 (3069363) 3069363..3069737 - 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
MM431_RS15135 (3069828) 3069828..3070181 - 354 WP_001285568.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
MM431_RS15140 (3070257) 3070257..3070478 - 222 WP_000692357.1 DUF987 domain-containing protein -
MM431_RS15145 (3070541) 3070541..3071017 - 477 WP_001186756.1 RadC family protein -
MM431_RS15150 (3071033) 3071033..3071203 - 171 Protein_2984 antirestriction protein -
MM431_RS15155 (3071203) 3071203..3071658 - 456 Protein_2985 patatin-like phospholipase family protein -
MM431_RS15160 (3071655) 3071655..3072266 - 612 Protein_2986 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T237679 WP_000771609.1 NZ_CP093068:c3069737-3069363 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T237679 NZ_LR882499:1774734-1775138 [Mycobacterium tuberculosis variant microti OV254]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT237679 WP_001285568.1 NZ_CP093068:c3070181-3069828 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp

>AT237679 NZ_LR882499:1774525-1774728 [Mycobacterium tuberculosis variant microti OV254]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References