Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2455348..2455874 | Replicon | chromosome |
| Accession | NZ_CP093068 | ||
| Organism | Escherichia coli strain BR1220 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | MM431_RS11945 | Protein ID | WP_000323025.1 |
| Coordinates | 2455587..2455874 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | MM431_RS11940 | Protein ID | WP_000534858.1 |
| Coordinates | 2455348..2455587 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MM431_RS11905 (2450462) | 2450462..2450713 | + | 252 | Protein_2343 | DUF977 family protein | - |
| MM431_RS11910 (2450710) | 2450710..2451199 | + | 490 | Protein_2344 | class I SAM-dependent methyltransferase | - |
| MM431_RS11915 (2451677) | 2451677..2452098 | + | 422 | Protein_2345 | hypothetical protein | - |
| MM431_RS11920 (2452754) | 2452754..2453776 | + | 1023 | Protein_2346 | ISNCY family transposase | - |
| MM431_RS11925 (2453897) | 2453897..2454046 | + | 150 | WP_011443592.1 | protein YdfW | - |
| MM431_RS11930 (2454483) | 2454483..2454815 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| MM431_RS11935 (2455018) | 2455018..2455323 | - | 306 | WP_001326990.1 | protein YdfV | - |
| MM431_RS11940 (2455348) | 2455348..2455587 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| MM431_RS11945 (2455587) | 2455587..2455874 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| MM431_RS11950 (2455946) | 2455946..2456101 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| MM431_RS11955 (2456318) | 2456318..2456569 | + | 252 | WP_000980994.1 | protein Rem | - |
| MM431_RS11960 (2456636) | 2456636..2456914 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| MM431_RS11965 (2456916) | 2456916..2457965 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| MM431_RS11970 (2457979) | 2457979..2458731 | + | 753 | WP_001047135.1 | antitermination protein | - |
| MM431_RS11975 (2459009) | 2459009..2459098 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| MM431_RS11980 (2459153) | 2459153..2459365 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| MM431_RS11985 (2459666) | 2459666..2459881 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| MM431_RS11990 (2460245) | 2460245..2460415 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| MM431_RS11995 (2460635) | 2460635..2460850 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2446852..2470526 | 23674 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T237674 WP_000323025.1 NZ_CP093068:2455587-2455874 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T237674 NZ_LR882499:1386677-1387108 [Mycobacterium tuberculosis variant microti OV254]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT237674 WP_000534858.1 NZ_CP093068:2455348-2455587 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT237674 NZ_LR882499:1386420-1386680 [Mycobacterium tuberculosis variant microti OV254]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|