Detailed information of TA system TA023767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/NGN_SP-AbrB
• Location: 246911..247508
• Replicon: chromosome
• Accession: NC_012623
• Organism: Sulfolobus islandicus Y.N.15.51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C3NKH9
• Locus tag: YN1551_RS01340
• Protein ID: WP_012716716.1
• Coordinates: 246911..247294 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C3NKI0
• Locus tag: YN1551_RS01345
• Protein ID: WP_012717047.1
• Coordinates: 247278..247508 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YN1551_RS01310 (YN1551_0272)	242768..243055	+	288	WP_012712409.1	ferredoxin family protein	-
YN1551_RS01315 (YN1551_0273)	243230..244263	+	1034	Protein_267	ISH3 family transposase	-
YN1551_RS16445 (YN1551_0274)	244281..244652	+	372	Protein_268	transposase	-
YN1551_RS01325 (YN1551_0275)	244690..245167	-	478	Protein_269	IS5/IS1182 family transposase	-
YN1551_RS01330 (YN1551_0276)	245324..245593	+	270	WP_012716719.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
YN1551_RS01335 (YN1551_0277)	245580..245969	+	390	WP_012716718.1	type II toxin-antitoxin system VapC family toxin	-
YN1551_RS17290 (YN1551_3229)	246241..246357	-	117	WP_238527883.1	hypothetical protein	-
YN1551_RS01340 (YN1551_0279)	246911..247294	-	384	WP_012716716.1	type II toxin-antitoxin system VapC family toxin	Toxin
YN1551_RS01345 (YN1551_0280)	247278..247508	-	231	WP_012717047.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YN1551_RS01350 (YN1551_0281)	248088..249239	+	1152	WP_012717048.1	IS110 family transposase	-
YN1551_RS01360 (YN1551_0282)	249434..250480	+	1047	Protein_276	ISH3 family transposase	-
YN1551_RS01365 (YN1551_0283)	250539..251477	-	939	WP_012714469.1	PEP/pyruvate-binding domain-containing protein	-
YN1551_RS01370 (YN1551_0284)	251540..252307	-	768	WP_012716713.1	formate dehydrogenase accessory sulfurtransferase FdhD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	238580..250480	11900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14364.76 Da
• Isoelectric Point: 9.4868

>T23767 WP_012716716.1 NC_012623:c247294-246911 [Sulfolobus islandicus Y.N.15.51]
VKVVLDASTLILYFYGNKKAKEIIEKNMNEAFVNSVNLTEFLYSYAKVKGWKESLLKYSLIRNTFELIDVNDEDIIKSTA
KLKIKYNLSLGDAFLLASAKSINSTAVTSDHELSKVKEVKVILIPKE

Nucleotide

• Length: 384 bp

>T23767 NC_012623:c247294-246911 [Sulfolobus islandicus Y.N.15.51]
GTGAAAGTAGTACTTGACGCCTCTACATTAATTTTGTATTTTTATGGAAATAAAAAAGCAAAAGAGATAATAGAGAAAAA
TATGAATGAGGCTTTTGTAAATTCAGTAAATCTTACAGAATTCCTTTATTCATACGCAAAAGTCAAAGGTTGGAAAGAAT
CCCTATTAAAATATTCTTTAATAAGAAACACCTTTGAGCTAATAGATGTTAACGATGAGGATATAATTAAAAGCACAGCT
AAGTTGAAAATTAAGTATAACCTCTCCTTAGGAGATGCTTTTTTATTAGCATCTGCTAAAAGTATAAATTCAACAGCTGT
AACGAGCGATCACGAGCTTAGTAAAGTTAAAGAGGTTAAGGTAATACTGATTCCTAAGGAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9079.39 Da
• Isoelectric Point: 5.2482

>AT23767 WP_012717047.1 NC_012623:c247508-247278 [Sulfolobus islandicus Y.N.15.51]
MYRLKVYKKGIIVIPKEIREKFNLKEGDEVNVIVDDDGIYIFPRDDIRKYFGSDKDAIKALDILEEERRRERESST

Nucleotide

• Length: 231 bp

>AT23767 NC_012623:c247508-247278 [Sulfolobus islandicus Y.N.15.51]
ATGTATAGATTGAAGGTGTATAAGAAAGGTATTATTGTAATACCGAAGGAGATAAGAGAAAAATTCAACTTGAAAGAAGG
TGACGAAGTTAACGTTATAGTTGACGATGATGGAATTTATATATTTCCTCGTGATGATATTAGAAAATACTTTGGTAGTG
ACAAGGACGCAATAAAAGCTTTAGACATTCTGGAAGAGGAGAGGAGAAGAGAACGTGAAAGTAGTACTTGA

Structures

Toxin

• AlphaFold DB: C3NKH9

Antitoxin

• AlphaFold DB: C3NKI0