Detailed information of TA system TA023766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 245324..245969
• Replicon: chromosome
• Accession: NC_012623
• Organism: Sulfolobus islandicus Y.N.15.51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C3NKH7
• Locus tag: YN1551_RS01335
• Protein ID: WP_012716718.1
• Coordinates: 245580..245969 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C3NKH6
• Locus tag: YN1551_RS01330
• Protein ID: WP_012716719.1
• Coordinates: 245324..245593 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YN1551_RS01305 (YN1551_0271)	241584..242771	+	1188	WP_012716722.1	NAD(P)/FAD-dependent oxidoreductase	-
YN1551_RS01310 (YN1551_0272)	242768..243055	+	288	WP_012712409.1	ferredoxin family protein	-
YN1551_RS01315 (YN1551_0273)	243230..244263	+	1034	Protein_267	ISH3 family transposase	-
YN1551_RS16445 (YN1551_0274)	244281..244652	+	372	Protein_268	transposase	-
YN1551_RS01325 (YN1551_0275)	244690..245167	-	478	Protein_269	IS5/IS1182 family transposase	-
YN1551_RS01330 (YN1551_0276)	245324..245593	+	270	WP_012716719.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YN1551_RS01335 (YN1551_0277)	245580..245969	+	390	WP_012716718.1	type II toxin-antitoxin system VapC family toxin	Toxin
YN1551_RS17290 (YN1551_3229)	246241..246357	-	117	WP_238527883.1	hypothetical protein	-
YN1551_RS01340 (YN1551_0279)	246911..247294	-	384	WP_012716716.1	type II toxin-antitoxin system VapC family toxin	-
YN1551_RS01345 (YN1551_0280)	247278..247508	-	231	WP_012717047.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
YN1551_RS01350 (YN1551_0281)	248088..249239	+	1152	WP_012717048.1	IS110 family transposase	-
YN1551_RS01360 (YN1551_0282)	249434..250480	+	1047	Protein_276	ISH3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	238580..250480	11900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• SpoVT-AbrB domain (4-46)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15197.66 Da
• Isoelectric Point: 4.7760

>T23766 WP_012716718.1 NC_012623:245580-245969 [Sulfolobus islandicus Y.N.15.51]
MIFLDANFIIYLNLGVKEVENFYIKVLQEDRLALDPLVIDEVIYISKKKYNVNFNDTISFLDEIVLPNSLILPIRKEDYD
KAKEIMLQYNLKPSDAFHVAVMLNNSISKIISEDKDFDRTKEIHRVWIT

Nucleotide

• Length: 390 bp

>T23766 NC_012623:245580-245969 [Sulfolobus islandicus Y.N.15.51]
ATGATTTTTCTTGACGCAAACTTTATCATATACTTGAATTTGGGTGTAAAGGAAGTAGAAAATTTTTATATTAAAGTCCT
ACAAGAAGATCGACTAGCTTTAGACCCATTAGTTATAGATGAAGTAATTTATATTTCAAAGAAAAAATATAACGTGAACT
TTAACGATACAATAAGTTTTCTAGACGAGATCGTTTTACCTAACTCTCTCATCCTTCCTATAAGAAAAGAAGATTATGAT
AAAGCAAAAGAGATAATGCTACAATATAACCTAAAGCCTTCAGACGCATTTCACGTTGCCGTAATGTTAAATAACTCAAT
TAGTAAAATTATAAGTGAAGATAAGGATTTTGATAGAACTAAAGAAATACATAGAGTTTGGATAACTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10101.76 Da
• Isoelectric Point: 5.7469

>AT23766 WP_012716719.1 NC_012623:245324-245593 [Sulfolobus islandicus Y.N.15.51]
MTLKVEVGKKGYIIIPKDIRDLLGIKEGDKLILNVYDGKIILEPERKVDINEILKRLEGHHAKISAYAKSAKLGDLLYSS
LEEEFDDFS

Nucleotide

• Length: 270 bp

>AT23766 NC_012623:245324-245593 [Sulfolobus islandicus Y.N.15.51]
TTGACTCTAAAAGTGGAAGTTGGAAAGAAAGGTTACATAATTATTCCTAAGGATATCAGAGATCTCCTAGGCATAAAAGA
AGGTGACAAGCTTATTCTTAACGTCTATGACGGTAAAATTATCCTTGAACCTGAAAGGAAGGTTGACATTAATGAGATCT
TAAAAAGACTTGAGGGACATCACGCTAAAATATCCGCTTATGCAAAAAGCGCTAAATTAGGAGACTTGCTTTATTCGAGC
CTTGAGGAGGAATTTGATGATTTTTCTTGA

Structures

Toxin

• AlphaFold DB: C3NKH7

Antitoxin

• AlphaFold DB: C3NKH6