Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 49194..49995 | Replicon | chromosome |
| Accession | NZ_CP093068 | ||
| Organism | Escherichia coli strain BR1220 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A8B3KN85 |
| Locus tag | MM431_RS00255 | Protein ID | WP_001094439.1 |
| Coordinates | 49194..49571 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | MM431_RS00260 | Protein ID | WP_024183872.1 |
| Coordinates | 49618..49995 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MM431_RS00225 (44559) | 44559..45482 | - | 924 | WP_000535961.1 | carboxylate/amino acid/amine transporter | - |
| MM431_RS00230 (45593) | 45593..46777 | - | 1185 | WP_001172876.1 | sugar efflux transporter | - |
| MM431_RS00235 (47174) | 47174..47335 | - | 162 | Protein_46 | RhuM family protein | - |
| MM431_RS00240 (47570) | 47570..48415 | - | 846 | WP_241468725.1 | DUF4942 domain-containing protein | - |
| MM431_RS00245 (48500) | 48500..48697 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| MM431_RS00250 (48709) | 48709..49197 | - | 489 | WP_241468726.1 | DUF5983 family protein | - |
| MM431_RS00255 (49194) | 49194..49571 | - | 378 | WP_001094439.1 | TA system toxin CbtA family protein | Toxin |
| MM431_RS00260 (49618) | 49618..49995 | - | 378 | WP_024183872.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| MM431_RS00265 (50071) | 50071..50292 | - | 222 | WP_000692306.1 | DUF987 domain-containing protein | - |
| MM431_RS00270 (50361) | 50361..50837 | - | 477 | WP_001186767.1 | RadC family protein | - |
| MM431_RS00275 (50853) | 50853..51326 | - | 474 | WP_000855069.1 | antirestriction protein | - |
| MM431_RS00280 (51420) | 51420..51665 | - | 246 | WP_000680586.1 | hypothetical protein | - |
| MM431_RS00285 (51665) | 51665..52483 | - | 819 | WP_241468727.1 | DUF932 domain-containing protein | - |
| MM431_RS00290 (52583) | 52583..52756 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| MM431_RS00295 (52876) | 52876..53118 | - | 243 | WP_000348966.1 | DNA polymerase III subunit gamma/tau | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 53322..53825 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13922.84 Da Isoelectric Point: 6.6347
>T237659 WP_001094439.1 NZ_CP093068:c49571-49194 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDIILGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDIILGKHPEAKQ
Download Length: 378 bp
>T237659 NZ_LR882499:c696871-696479 [Mycobacterium tuberculosis variant microti OV254]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13696.46 Da Isoelectric Point: 6.2021
>AT237659 WP_024183872.1 NZ_CP093068:c49995-49618 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGGPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPTITV
VSDTLPGTTHPDDNHDRPWWGGPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPTITV
Download Length: 378 bp
>AT237659 NZ_LR882499:c697125-696868 [Mycobacterium tuberculosis variant microti OV254]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|