Detailed information of TA system TA023765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 2380816..2381461
• Replicon: chromosome
• Accession: NC_012622
• Organism: Sulfolobus islandicus Y.G.57.14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C3NKH7
• Locus tag: YG5714_RS12900
• Protein ID: WP_012716718.1
• Coordinates: 2380816..2381205 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C3NKH6
• Locus tag: YG5714_RS12905
• Protein ID: WP_012716719.1
• Coordinates: 2381192..2381461 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YG5714_RS12875 (YG5714_2629)	2376316..2377352	-	1037	Protein_2627	ISH3 family transposase	-
YG5714_RS12885 (YG5714_2631)	2377547..2378698	-	1152	WP_012715803.1	IS110 family transposase	-
YG5714_RS12890 (YG5714_2632)	2379278..2379508	+	231	WP_012714470.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
YG5714_RS12895 (YG5714_2633)	2379492..2379875	+	384	WP_012716716.1	type II toxin-antitoxin system VapC family toxin	-
YG5714_RS15330 (YG5714_2634)	2380429..2380605	+	177	WP_238526255.1	hypothetical protein	-
YG5714_RS12900 (YG5714_2635)	2380816..2381205	-	390	WP_012716718.1	type II toxin-antitoxin system VapC family toxin	Toxin
YG5714_RS12905 (YG5714_2636)	2381192..2381461	-	270	WP_012716719.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YG5714_RS12910 (YG5714_2637)	2381618..2381965	+	348	Protein_2634	IS5/IS1182 family transposase	-
YG5714_RS15720 (YG5714_2638)	2382012..2382383	-	372	Protein_2635	transposase	-
YG5714_RS12920 (YG5714_2639)	2382401..2383434	-	1034	Protein_2636	ISH3 family transposase	-
YG5714_RS12925 (YG5714_2641)	2383609..2383896	-	288	WP_012712409.1	ferredoxin family protein	-
YG5714_RS12930 (YG5714_2642)	2383893..2385080	-	1188	WP_012716722.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2376405..2383375	6970

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• SpoVT-AbrB domain (4-46)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15197.66 Da
• Isoelectric Point: 4.7760

>T23765 WP_012716718.1 NC_012622:c2381205-2380816 [Sulfolobus islandicus Y.G.57.14]
MIFLDANFIIYLNLGVKEVENFYIKVLQEDRLALDPLVIDEVIYISKKKYNVNFNDTISFLDEIVLPNSLILPIRKEDYD
KAKEIMLQYNLKPSDAFHVAVMLNNSISKIISEDKDFDRTKEIHRVWIT

Nucleotide

• Length: 390 bp

>T23765 NC_012622:c2381205-2380816 [Sulfolobus islandicus Y.G.57.14]
ATGATTTTTCTTGACGCAAACTTTATCATATACTTGAATTTGGGTGTAAAGGAAGTAGAAAATTTTTATATTAAAGTCCT
ACAAGAAGATCGACTAGCTTTAGACCCATTAGTTATAGATGAAGTAATTTATATTTCAAAGAAAAAATATAACGTGAACT
TTAACGATACAATAAGTTTTCTAGACGAGATCGTTTTACCTAACTCTCTCATCCTTCCTATAAGAAAAGAAGATTATGAT
AAAGCAAAAGAGATAATGCTACAATATAACCTAAAGCCTTCAGACGCATTTCACGTTGCCGTAATGTTAAATAACTCAAT
TAGTAAAATTATAAGTGAAGATAAGGATTTTGATAGAACTAAAGAAATACATAGAGTTTGGATAACTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10101.76 Da
• Isoelectric Point: 5.7469

>AT23765 WP_012716719.1 NC_012622:c2381461-2381192 [Sulfolobus islandicus Y.G.57.14]
MTLKVEVGKKGYIIIPKDIRDLLGIKEGDKLILNVYDGKIILEPERKVDINEILKRLEGHHAKISAYAKSAKLGDLLYSS
LEEEFDDFS

Nucleotide

• Length: 270 bp

>AT23765 NC_012622:c2381461-2381192 [Sulfolobus islandicus Y.G.57.14]
TTGACTCTAAAAGTGGAAGTTGGAAAGAAAGGTTACATAATTATTCCTAAGGATATCAGAGATCTCCTAGGCATAAAAGA
AGGTGACAAGCTTATTCTTAACGTCTATGACGGTAAAATTATCCTTGAACCTGAAAGGAAGGTTGACATTAATGAGATCT
TAAAAAGACTTGAGGGACATCACGCTAAAATATCCGCTTATGCAAAAAGCGCTAAATTAGGAGACTTGCTTTATTCGAGC
CTTGAGGAGGAATTTGATGATTTTTCTTGA

Structures

Toxin

• AlphaFold DB: C3NKH7

Antitoxin

• AlphaFold DB: C3NKH6