Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/ParE(toxin)
Location 1791382..1791857 Replicon chromosome
Accession NZ_CP093045
Organism Bartonella krasnovii strain 36C_7b

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag MNL01_RS07775 Protein ID WP_120121236.1
Coordinates 1791382..1791669 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag MNL01_RS07780 Protein ID WP_120121238.1
Coordinates 1791669..1791857 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL01_RS07750 (MNL01_07750) 1786932..1787452 - 521 Protein_1506 DUF1465 family protein -
MNL01_RS07755 (MNL01_07755) 1787653..1788852 - 1200 Protein_1507 OpgC domain-containing protein -
MNL01_RS07760 (MNL01_07760) 1789128..1789790 + 663 WP_120121233.1 thiamine phosphate synthase -
MNL01_RS07765 (MNL01_07765) 1790393..1790794 + 402 WP_120122708.1 helix-turn-helix transcriptional regulator -
MNL01_RS07770 (MNL01_07770) 1790801..1791022 + 222 WP_148255698.1 hypothetical protein -
MNL01_RS07775 (MNL01_07775) 1791382..1791669 - 288 WP_120121236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL01_RS07780 (MNL01_07780) 1791669..1791857 - 189 WP_120121238.1 antitoxin Antitoxin
MNL01_RS07785 (MNL01_07785) 1792361..1792729 + 369 WP_120121240.1 helix-turn-helix transcriptional regulator -
MNL01_RS07790 (MNL01_07790) 1793052..1793464 + 413 Protein_1514 hypothetical protein -
MNL01_RS07795 (MNL01_07795) 1793727..1793924 + 198 WP_241440184.1 hypothetical protein -
MNL01_RS07800 (MNL01_07800) 1794668..1795711 + 1044 WP_120121242.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11097.98 Da        Isoelectric Point: 10.1866

>T237649 WP_120121236.1 NZ_CP093045:c1791669-1791382 [Bartonella krasnovii]
MLPVVWLSSARDDLRQILTYIARENPSAARRMKRFLETSVLPLAEHPYLYRQSERILGLREIIAHPNYLILYRVAANQIE
IVAVVHARREFPTSL

Download         Length: 288 bp

>T237649 NZ_LR882498:c3710373-3709945 [Mycobacterium tuberculosis variant microti]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGCGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7068.01 Da        Isoelectric Point: 4.3167

>AT237649 WP_120121238.1 NZ_CP093045:c1791857-1791669 [Bartonella krasnovii]
MKNTLSPFISEFETIEQESSHTAWLRDKVAISLANLSPPIPHDEVMAEMDVIISQLENEQKK

Download         Length: 189 bp

>AT237649 NZ_LR882498:c3710619-3710377 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References