Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 1075760..1076333 Replicon chromosome
Accession NZ_CP093045
Organism Bartonella krasnovii strain 36C_7b

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL01_RS04615 Protein ID WP_120122373.1
Coordinates 1075760..1076068 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL01_RS04620 Protein ID WP_120122374.1
Coordinates 1076049..1076333 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL01_RS04590 (MNL01_04590) 1072059..1072196 - 138 WP_167309298.1 hypothetical protein -
MNL01_RS04595 (MNL01_04595) 1072208..1073089 - 882 WP_120122370.1 hypothetical protein -
MNL01_RS04600 (MNL01_04600) 1073091..1073516 - 426 WP_120122371.1 hypothetical protein -
MNL01_RS04605 (MNL01_04605) 1073516..1074976 - 1461 WP_120122372.1 hypothetical protein -
MNL01_RS04610 (MNL01_04610) 1074978..1075685 - 708 WP_120122787.1 hypothetical protein -
MNL01_RS04615 (MNL01_04615) 1075760..1076068 + 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL01_RS04620 (MNL01_04620) 1076049..1076333 + 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL01_RS04625 (MNL01_04625) 1076369..1076749 - 381 WP_120122375.1 hypothetical protein -
MNL01_RS04630 (MNL01_04630) 1076775..1077899 - 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL01_RS04635 (MNL01_04635) 1077993..1078877 - 885 WP_120122377.1 hypothetical protein -
MNL01_RS04640 (MNL01_04640) 1078890..1080572 - 1683 WP_241436388.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1057004..1121388 64384


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237648 WP_120122373.1 NZ_CP093045:1075760-1076068 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237648 NZ_LR882498:3552747-3553091 [Mycobacterium tuberculosis variant microti]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237648 WP_120122374.1 NZ_CP093045:1076049-1076333 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237648 NZ_LR882498:3553088-3553417 [Mycobacterium tuberculosis variant microti]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References