Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 922977..923566 Replicon chromosome
Accession NZ_CP093045
Organism Bartonella krasnovii strain 36C_7b

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MNL01_RS03850 Protein ID WP_120122258.1
Coordinates 923234..923566 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MNL01_RS03845 Protein ID WP_120122257.1
Coordinates 922977..923234 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL01_RS03815 (MNL01_03815) 918259..919446 + 1188 WP_120122252.1 DUF1376 domain-containing protein -
MNL01_RS03820 (MNL01_03820) 919430..919810 + 381 WP_174767382.1 hypothetical protein -
MNL01_RS03825 (MNL01_03825) 919993..920502 + 510 WP_120122253.1 hypothetical protein -
MNL01_RS03830 (MNL01_03830) 920751..921614 + 864 WP_120122254.1 hypothetical protein -
MNL01_RS03835 (MNL01_03835) 921890..922333 + 444 WP_120122255.1 single-stranded DNA-binding protein -
MNL01_RS03840 (MNL01_03840) 922388..922882 + 495 WP_120122256.1 hypothetical protein -
MNL01_RS03845 (MNL01_03845) 922977..923234 + 258 WP_120122257.1 antitoxin Antitoxin
MNL01_RS03850 (MNL01_03850) 923234..923566 + 333 WP_120122258.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNL01_RS03855 (MNL01_03855) 923754..924464 - 711 WP_120122259.1 hypothetical protein -
MNL01_RS03860 (MNL01_03860) 924772..925107 + 336 WP_120122260.1 hypothetical protein -
MNL01_RS03865 (MNL01_03865) 925088..926413 + 1326 WP_120122261.1 phage terminase large subunit -
MNL01_RS03870 (MNL01_03870) 926398..928446 + 2049 WP_120122262.1 portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 868353..945273 76920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11853.95 Da        Isoelectric Point: 10.5590

>T237647 WP_120122258.1 NZ_CP093045:923234-923566 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Download         Length: 333 bp

>T237647 NZ_LR882498:3180739-3181182 [Mycobacterium tuberculosis variant microti]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9346.69 Da        Isoelectric Point: 3.8857

>AT237647 WP_120122257.1 NZ_CP093045:922977-923234 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Download         Length: 258 bp

>AT237647 NZ_LR882498:3180495-3180752 [Mycobacterium tuberculosis variant microti]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References