Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 884255..884828 Replicon chromosome
Accession NZ_CP093044
Organism Bartonella krasnovii strain 90B_7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL02_RS03570 Protein ID WP_120122373.1
Coordinates 884520..884828 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL02_RS03565 Protein ID WP_120122374.1
Coordinates 884255..884539 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL02_RS03545 (MNL02_03545) 879680..881698 + 2019 WP_241436961.1 portal protein -
MNL02_RS03550 (MNL02_03550) 881711..882595 + 885 WP_120122377.1 hypothetical protein -
MNL02_RS03555 (MNL02_03555) 882689..883813 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL02_RS03560 (MNL02_03560) 883839..884219 + 381 WP_120122375.1 hypothetical protein -
MNL02_RS03565 (MNL02_03565) 884255..884539 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL02_RS03570 (MNL02_03570) 884520..884828 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL02_RS03575 (MNL02_03575) 884903..885610 + 708 WP_120122787.1 hypothetical protein -
MNL02_RS03580 (MNL02_03580) 885612..887072 + 1461 WP_120122372.1 hypothetical protein -
MNL02_RS03585 (MNL02_03585) 887072..887497 + 426 WP_120122371.1 hypothetical protein -
MNL02_RS03590 (MNL02_03590) 887499..888380 + 882 WP_120122370.1 hypothetical protein -
MNL02_RS03595 (MNL02_03595) 888392..888529 + 138 WP_167309298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 754871..908470 153599
- inside Prophage - - 751793..903238 151445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237645 WP_120122373.1 NZ_CP093044:c884828-884520 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237645 NZ_LR882498:c3134369-3133977 [Mycobacterium tuberculosis variant microti]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237645 WP_120122374.1 NZ_CP093044:c884539-884255 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237645 NZ_LR882498:c3134581-3134366 [Mycobacterium tuberculosis variant microti]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References