Detailed information of TA system TA237643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 1022074..1022663
• Replicon: chromosome
• Accession: NZ_CP093043
• Organism: Bartonella krasnovii strain 51A_7

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: MNL03_RS04440
• Protein ID: WP_120122258.1
• Coordinates: 1022074..1022406 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: MNL03_RS04445
• Protein ID: WP_120122257.1
• Coordinates: 1022406..1022663 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNL03_RS04410 (MNL03_04410)	1017534..1018223	+	690	WP_241439912.1	hypothetical protein	-
MNL03_RS04415 (MNL03_04415)	1018319..1019098	+	780	WP_241439913.1	hypothetical protein	-
MNL03_RS04420 (MNL03_04420)	1019831..1020181	+	351	WP_241436930.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MNL03_RS04425 (MNL03_04425)	1020183..1020506	+	324	WP_241436929.1	helix-turn-helix transcriptional regulator	-
MNL03_RS04430 (MNL03_04430)	1020665..1020853	-	189	Protein_866	hypothetical protein	-
MNL03_RS04435 (MNL03_04435)	1021176..1021886	+	711	WP_120122259.1	hypothetical protein	-
MNL03_RS04440 (MNL03_04440)	1022074..1022406	-	333	WP_120122258.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MNL03_RS04445 (MNL03_04445)	1022406..1022663	-	258	WP_120122257.1	antitoxin	Antitoxin
MNL03_RS04450 (MNL03_04450)	1022758..1023252	-	495	WP_120122256.1	hypothetical protein	-
MNL03_RS04455 (MNL03_04455)	1023307..1023750	-	444	WP_120122255.1	single-stranded DNA-binding protein	-
MNL03_RS04460 (MNL03_04460)	1024026..1024889	-	864	WP_120122254.1	hypothetical protein	-
MNL03_RS04465 (MNL03_04465)	1025138..1025647	-	510	WP_120122253.1	hypothetical protein	-
MNL03_RS04470 (MNL03_04470)	1025830..1026210	-	381	WP_241440088.1	hypothetical protein	-
MNL03_RS04475 (MNL03_04475)	1026194..1027339	-	1146	WP_241440089.1	YdaU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	981554..1038363	56809

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11853.95 Da
• Isoelectric Point: 10.5590

>T237643 WP_120122258.1 NZ_CP093043:c1022406-1022074 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT

Nucleotide

• Length: 333 bp

>T237643 NZ_LR882498:c3111928-3111572 [Mycobacterium tuberculosis variant microti]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9346.69 Da
• Isoelectric Point: 3.8857

>AT237643 WP_120122257.1 NZ_CP093043:c1022663-1022406 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPVLLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSVDFADEDIEWFDAQPV
GSELL

Nucleotide

• Length: 258 bp

>AT237643 NZ_LR882498:c3112142-3111912 [Mycobacterium tuberculosis variant microti]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA