Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 1000527..1001100 Replicon chromosome
Accession NZ_CP093043
Organism Bartonella krasnovii strain 51A_7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL03_RS04350 Protein ID WP_120122373.1
Coordinates 1000527..1000835 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL03_RS04355 Protein ID WP_120122374.1
Coordinates 1000816..1001100 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL03_RS04325 (MNL03_04325) 996826..996963 - 138 WP_167309298.1 hypothetical protein -
MNL03_RS04330 (MNL03_04330) 996975..997856 - 882 WP_120122370.1 hypothetical protein -
MNL03_RS04335 (MNL03_04335) 997858..998283 - 426 WP_120122371.1 hypothetical protein -
MNL03_RS04340 (MNL03_04340) 998283..999743 - 1461 WP_120122372.1 hypothetical protein -
MNL03_RS04345 (MNL03_04345) 999745..1000452 - 708 WP_120122787.1 hypothetical protein -
MNL03_RS04350 (MNL03_04350) 1000527..1000835 + 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL03_RS04355 (MNL03_04355) 1000816..1001100 + 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL03_RS04360 (MNL03_04360) 1001136..1001516 - 381 WP_120122375.1 hypothetical protein -
MNL03_RS04365 (MNL03_04365) 1001542..1002666 - 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL03_RS04370 (MNL03_04370) 1002760..1003647 - 888 WP_241440086.1 hypothetical protein -
MNL03_RS04375 (MNL03_04375) 1003660..1004829 - 1170 Protein_855 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 981554..1038363 56809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237642 WP_120122373.1 NZ_CP093043:1000527-1000835 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237642 NZ_LR882498:c3072687-3072292 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCGGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237642 WP_120122374.1 NZ_CP093043:1000816-1001100 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237642 NZ_LR882498:c3072266-3072000 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References