Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 1020434..1021023 | Replicon | chromosome |
| Accession | NZ_CP093041 | ||
| Organism | Bartonella krasnovii strain 87B_3 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | MNL05_RS04285 | Protein ID | WP_120122258.1 |
| Coordinates | 1020434..1020766 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | MNL05_RS04290 | Protein ID | WP_241436376.1 |
| Coordinates | 1020766..1021023 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNL05_RS04265 (MNL05_04265) | 1015626..1017638 | - | 2013 | WP_241439814.1 | portal protein | - |
| MNL05_RS04270 (MNL05_04270) | 1017623..1018948 | - | 1326 | WP_241439815.1 | phage terminase large subunit | - |
| MNL05_RS04275 (MNL05_04275) | 1018929..1019243 | - | 315 | WP_241439816.1 | hypothetical protein | - |
| MNL05_RS04280 (MNL05_04280) | 1019536..1020246 | + | 711 | WP_120122259.1 | hypothetical protein | - |
| MNL05_RS04285 (MNL05_04285) | 1020434..1020766 | - | 333 | WP_120122258.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MNL05_RS04290 (MNL05_04290) | 1020766..1021023 | - | 258 | WP_241436376.1 | antitoxin | Antitoxin |
| MNL05_RS04295 (MNL05_04295) | 1021118..1021604 | - | 487 | Protein_841 | hypothetical protein | - |
| MNL05_RS04300 (MNL05_04300) | 1021659..1022102 | - | 444 | WP_241439817.1 | single-stranded DNA-binding protein | - |
| MNL05_RS04305 (MNL05_04305) | 1022493..1022576 | + | 84 | WP_241436487.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNL05_RS04310 (MNL05_04310) | 1022593..1022886 | + | 294 | WP_034988160.1 | HigA family addiction module antitoxin | - |
| MNL05_RS04315 (MNL05_04315) | 1022925..1023212 | - | 288 | WP_241436486.1 | hypothetical protein | - |
| MNL05_RS04320 (MNL05_04320) | 1023429..1023629 | - | 201 | WP_241439818.1 | hypothetical protein | - |
| MNL05_RS04325 (MNL05_04325) | 1023702..1023919 | + | 218 | Protein_847 | hypothetical protein | - |
| MNL05_RS04330 (MNL05_04330) | 1023922..1024954 | + | 1033 | Protein_848 | tyrosine-type recombinase/integrase | - |
| MNL05_RS04335 (MNL05_04335) | 1025010..1025309 | - | 300 | WP_120122206.1 | HigA family addiction module antitoxin | - |
| MNL05_RS04340 (MNL05_04340) | 1025325..1025606 | - | 282 | WP_120122205.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 979819..1030791 | 50972 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11853.95 Da Isoelectric Point: 10.5590
>T237638 WP_120122258.1 NZ_CP093041:c1020766-1020434 [Bartonella krasnovii]
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
MKRGEIWLVSLDPSSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFARTAGFAVSLMGVGLHTTGVIRCDQPRAL
DIGARQGKKMETVPPMIMNEVLAKLATFLT
Download Length: 333 bp
>T237638 NZ_LR882498:c2871547-2871152 [Mycobacterium tuberculosis variant microti]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9334.59 Da Isoelectric Point: 3.8225
>AT237638 WP_241436376.1 NZ_CP093041:c1021023-1020766 [Bartonella krasnovii]
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
MYTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLIVKPQTFPSYTLDELLAQCNPSDDFADEDIEWFDAQPV
GSELL
Download Length: 258 bp
>AT237638 NZ_LR882498:c2871789-2871544 [Mycobacterium tuberculosis variant microti]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|