Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 843032..843605 Replicon chromosome
Accession NZ_CP093041
Organism Bartonella krasnovii strain 87B_3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNL05_RS03435 Protein ID WP_120122373.1
Coordinates 843297..843605 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNL05_RS03430 Protein ID WP_120122374.1
Coordinates 843032..843316 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL05_RS03410 (MNL05_03410) 839306..840475 + 1170 Protein_668 phage portal protein -
MNL05_RS03415 (MNL05_03415) 840488..841372 + 885 WP_120122377.1 hypothetical protein -
MNL05_RS03420 (MNL05_03420) 841466..842590 + 1125 WP_120122376.1 N4-gp56 family major capsid protein -
MNL05_RS03425 (MNL05_03425) 842616..842996 + 381 WP_120122375.1 hypothetical protein -
MNL05_RS03430 (MNL05_03430) 843032..843316 - 285 WP_120122374.1 putative addiction module antidote protein Antitoxin
MNL05_RS03435 (MNL05_03435) 843297..843605 - 309 WP_120122373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNL05_RS03440 (MNL05_03440) 843680..844387 + 708 WP_120122787.1 hypothetical protein -
MNL05_RS03445 (MNL05_03445) 844389..845849 + 1461 WP_120122372.1 hypothetical protein -
MNL05_RS03450 (MNL05_03450) 845849..846274 + 426 WP_120122371.1 hypothetical protein -
MNL05_RS03455 (MNL05_03455) 846276..847157 + 882 WP_120122370.1 hypothetical protein -
MNL05_RS03460 (MNL05_03460) 847169..847306 + 138 WP_167309298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 796601..862578 65977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Uncharacterized protein HI1420

(13-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11857.83 Da        Isoelectric Point: 9.7095

>T237637 WP_120122373.1 NZ_CP093041:c843605-843297 [Bartonella krasnovii]
MILIHKTIEFDTWLKKLKDKSVKAIILQRVVRLKQGLFGDVKFFHGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T237637 NZ_LR882498:2870285-2870662 [Mycobacterium tuberculosis variant microti]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10191.69 Da        Isoelectric Point: 9.6249

>AT237637 WP_120122374.1 NZ_CP093041:c843316-843032 [Bartonella krasnovii]
MKITPFKPEEYLKDIESQKIFLNEALKTGDAAHIADALGIVARAQNMSALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Download         Length: 285 bp

>AT237637 NZ_LR882498:2870031-2870288 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References