Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 258527..259074 Replicon chromosome
Accession NZ_CP093041
Organism Bartonella krasnovii strain 87B_3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MNL05_RS00890 Protein ID WP_241439656.1
Coordinates 258751..259074 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MNL05_RS00885 Protein ID WP_241439655.1
Coordinates 258527..258751 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNL05_RS00845 (MNL05_00845) 254173..255330 + 1158 Protein_163 integrase arm-type DNA-binding domain-containing protein -
MNL05_RS00850 (MNL05_00850) 255816..256346 + 531 WP_241439652.1 antA/AntB antirepressor family protein -
MNL05_RS00855 (MNL05_00855) 256467..256742 + 276 WP_241436175.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
MNL05_RS00860 (MNL05_00860) 256755..257036 + 282 WP_241436177.1 type II toxin-antitoxin system YafQ family toxin -
MNL05_RS00865 (MNL05_00865) 257159..257371 - 213 WP_241436178.1 hypothetical protein -
MNL05_RS00870 (MNL05_00870) 257364..257567 - 204 WP_241436179.1 hypothetical protein -
MNL05_RS00875 (MNL05_00875) 257500..257718 - 219 WP_241436181.1 hypothetical protein -
MNL05_RS00880 (MNL05_00880) 257723..258385 - 663 WP_241439653.1 glycoside hydrolase family protein -
MNL05_RS00885 (MNL05_00885) 258527..258751 + 225 WP_241439655.1 antitoxin MazE family protein Antitoxin
MNL05_RS00890 (MNL05_00890) 258751..259074 + 324 WP_241439656.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNL05_RS00895 (MNL05_00895) 259105..260412 - 1308 WP_241439657.1 contractile injection system protein, VgrG/Pvc8 family -
MNL05_RS00900 (MNL05_00900) 260409..260633 - 225 WP_241439658.1 tail protein X -
MNL05_RS00905 (MNL05_00905) 260630..261010 - 381 WP_241439659.1 phage tail protein -
MNL05_RS00910 (MNL05_00910) 261016..263151 - 2136 WP_241439660.1 phage tail tape measure protein -
MNL05_RS08755 263148..263252 - 105 WP_277623159.1 GpE family phage tail protein -
MNL05_RS00920 (MNL05_00920) 263261..263546 - 286 Protein_178 phage tail assembly protein -
MNL05_RS00925 (MNL05_00925) 263549..264055 - 507 WP_241439823.1 phage major tail tube protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 250970..308213 57243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(7-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11792.06 Da        Isoelectric Point: 9.3681

>T237635 WP_241439656.1 NZ_CP093041:258751-259074 [Bartonella krasnovii]
MRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVTVLPITSTLIDAPLLRITIQPNDKNGLQKPSQVMIDKIMTVRCEKI
SPAFGFIPVDKMVEIERCLAVFLGIVK

Download         Length: 324 bp

>T237635 NZ_LR882498:c2856110-2855691 [Mycobacterium tuberculosis variant microti]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8703.95 Da        Isoelectric Point: 8.0564

>AT237635 WP_241439655.1 NZ_CP093041:258527-258751 [Bartonella krasnovii]
MGTMNVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECHRQTRLVAKMDKADTSLQLFMDQSLMDVDGWTE

Download         Length: 225 bp

>AT237635 NZ_LR882498:c2856331-2856107 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References